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Anti-Desmoglein 3 Antibody (CAB5227)

SKU:
CAB5227
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
€139 - €419
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-Desmoglein 3 Antibody
Antibody SKU:CAB5227
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human Desmoglein 3
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse
Positive Samples:A-431, Cal-27
Immunogen:A synthesized peptide derived from human Desmoglein 3
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:1830
Uniprot:P32926
Cellular Location:
Calculated MW:145kDa
Observed MW:145KDa
Synonyms:CDHF6, PVA
Background:This gene encodes a member of the desmoglein family and cadherin cell adhesion molecule superfamily of proteins. Desmogleins are calcium-binding transmembrane glycoprotein components of desmosomes, cell-cell junctions between epithelial, myocardial, and other cell types. The encoded preproprotein is proteolytically processed to generate the mature glycoprotein. This gene is present in a gene cluster with other desmoglein gene family members on chromosome 18. The encoded protein has been identified as the autoantigen of the autoimmune blistering disease pemphigus vulgaris. [provided by RefSeq, Jan 2016]
UniProt Protein Function:DSG3: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
UniProt Protein Details:

Protein type:Membrane protein, integral; Cell adhesion

Chromosomal Location of Human Ortholog: 18q12.1

Cellular Component: desmosome; plasma membrane; integral to membrane; cytosol

Molecular Function:calcium ion binding

Biological Process: apoptosis; homophilic cell adhesion; cell structure disassembly during apoptosis

NCBI Summary:Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. Desmoglein 3 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. This protein has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus vulgaris. [provided by RefSeq, Jul 2008]
UniProt Code:P32926
NCBI GenInfo Identifier:239938621
NCBI Gene ID:1830
NCBI Accession:P32926.2
UniProt Secondary Accession:P32926,A8K2V2,
UniProt Related Accession:P32926
Molecular Weight:107,533 Da
NCBI Full Name:Desmoglein-3
NCBI Synonym Full Names:desmoglein 3
NCBI Official Symbol:DSG3  
NCBI Official Synonym Symbols:PVA; CDHF6  
NCBI Protein Information:desmoglein-3; cadherin family member 6; pemphigus vulgaris antigen; 130-kD pemphigus vulgaris antigen; 130 kDa pemphigus vulgaris antigen
UniProt Protein Name:Desmoglein-3
UniProt Synonym Protein Names:130 kDa pemphigus vulgaris antigen; PVA; Cadherin family member 6
Protein Family:Desmoglein
UniProt Gene Name:DSG3  
UniProt Entry Name:DSG3_HUMAN
Anti-Desmoglein 3 Antibody (CAB5227)Western blot - Desmoglein 3 Rabbit mAb (CAB5227)

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