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[KO Validated] DNMT1 Rabbit Polyclonal Antibody (CAB5495)

SKU:
CAB5495
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling
  • KO Validated Antibodies 1 Anti-DNMT1 Antibody CAB5495KO Validated
  • KO Validated Antibodies 1 Anti-DNMT1 Antibody CAB5495KO Validated
  • KO Validated Antibodies 1 Anti-DNMT1 Antibody CAB5495KO Validated
  • KO Validated Antibodies 1 Anti-DNMT1 Antibody CAB5495KO Validated
€139 - €419
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Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:[KO Validated] DNMT1 Rabbit Polyclonal Antibody
SKU:CAB5495
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 760-1109 of DNMT1 (NP_001370.1).
Sequence:GDCV SVIP DDSS KPLY LARV TALW EDSS NGQM FHAH WFCA GTDT VLGA TSDP LELF LVDE CEDM QLSY IHSK VKVI YKAP SENW AMEG GMDP ESLL EGDD GKTY FYQL WYDQ DYAR FESP PKTQ PTED NKFK FCVS CARL AEMR QKEI PRVL EQLE DLDS RVLY YSAT KNGI LYRV GDGV YLPP EAFT FNIK LSSP VKRP RKEP VDED LYPE HYRK YSDY IKGS NLDA PEPY RIGR IKEI FCPK KSNG RPNE TDIK IRVN KFYR PENT HKST PASY HADI NLLY WSDE EAVV DFKA VQGR CTVE YGED LPEC VQVY SMGG PNRF YFLE AYNA KSKS FEDP PNHA RSPG NK
Tested Applications:WB IF/ICC IP ELISA
Recommended Dilution:WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells
Synonyms:AIM; DNMT; MCMT; CXXC9; HSN1E; ADCADN; m.HsaI; DNMT1
Positive Sample:293T,SW480
Conjugate:Unconjugated
Cellular Localization:Nucleus.
Calculated MW:183kDa
Observed MW:200kDa

This gene encodes an enzyme that transfers methyl groups to cytosine nucleotides of genomic DNA. This protein is the major enzyme responsible for maintaining methylation patterns following DNA replication and shows a preference for hemi-methylated DNA. Methylation of DNA is an important component of mammalian epigenetic gene regulation. Aberrant methylation patterns are found in human tumors and associated with developmental abnormalities. Variation in this gene has been associated with cerebellar ataxia, deafness, and narcolepsy, and neuropathy, hereditary sensory, type IE. Alternative splicing results in multiple transcript variants.

Purification Method:Affinity purification
Gene ID:1786
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Product ImageImmunoprecipitation analysis of 200 μg extracts of 293T cells using 3 μg DNMT1 antibody (CAB5495). Western blot was performed from the immunoprecipitate using DNMT1 antibody (CAB5495) at a dilution of 1:1000.

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