DP-2 Transcription Factor Activity Assay

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SKU:
TFAB00091
€699

Description

ELISA Kit Technical ManualMSDS

DP-2 Transcription Factor activity assay

Product Description:The ELISA Genie DP-2 transcription factor activity assay allows for the detection and qualitative analysis of endogenous levels of activated transcription factors in a variety of nuclear and cell lysates ELISA Genie ELISA kits are designed to significantly reduce experiment Time: and ensure sensitivity and flexibility for high-throughput screening.
Target Synonyms:E2F dimerization partner 2
Detection Target:Phospho-IRAK1(Thr209)
Reactivity:Human, Mouse, Rat
Pack Size:12 x 8-Well Microstrips
Detection Method:Colorimetric 450 nm
Format:transcription factor activity assay
Storage and Stability Guarantee:4°C/6 Months
Sample Type:Nuclear or cell lysates
Range:See Technical Manual
Time:4.5 hours

DP-2 Transcription Factor activity assay Protein Information

UniProt Protein Function:TFDP2: Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DP2/E2F complex functions in the control of cell-cycle progression from G1 to S phase. The E2F1/DP complex appears to mediate both cell proliferation and apoptosis. Belongs to the E2F/DP family. 6 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:DNA-binding

Chromosomal Location of Human Ortholog: 3q23

Cellular Component: nucleoplasm; transcription factor complex

Molecular Function:protein domain specific binding; DNA binding; transcription cofactor activity; transcription factor binding; transcription factor activity

Biological Process: transcription initiation from RNA polymerase II promoter; Notch signaling pathway; transcription, DNA-dependent; transforming growth factor beta receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; gene expression; mitotic cell cycle

NCBI Summary:The gene is a member of the transcription factor DP family. The encoded protein forms heterodimers with the E2F transcription factors resulting in transcriptional activation of cell cycle regulated genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
UniProt Code:Q14188
NCBI GenInfo Identifier:8039810
NCBI Gene ID:7029
NCBI Accession:Q14188.2
UniProt Related Accession:Q14188
Molecular Weight:
NCBI Full Name:Transcription factor Dp-2
NCBI Synonym Full Names:transcription factor Dp-2
NCBI Official Symbol:TFDP2
NCBI Official Synonym Symbols:DP2
NCBI Protein Information:transcription factor Dp-2
UniProt Protein Name:Transcription factor Dp-2
UniProt Synonym Protein Names:E2F dimerization partner 2
UniProt Gene Name:TFDP2
UniProt Entry Name:TFDP2_HUMAN
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