E2 Antibody (PACO34854)
- SKU:
- PACO34854
- Product Type:
- Antibody
- Reactivity:
- Virus
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | E2 Antibody (PACO34854) |
Antibody SKU: | PACO34854 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA |
Recommended Dilutions: | |
Species Reactivity: | Human papillomavirus type 18 |
Immunogen: | Recombinant Human papillomavirus type 18 Regulatory protein E2 protein (1-365AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Background: | E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication. |
Synonyms: | Regulatory protein E2, E2 |
UniProt Protein Function: | Plays a role in the initiation of viral DNA replication. A dimer of E2 interacts with a dimer of E1 in order to improve specificity of E1 DNA binding activity. Once the complex recognizes and binds DNA at specific sites, the E2 dimer is removed from DNA. E2 also regulates viral transcription through binding to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory regions of the viral genome. Activates or represses transcription depending on E2RE's position with regards to proximal promoter elements including the TATA-box. Repression occurs by sterically hindering the assembly of the transcription initiation complex. |
UniProt Protein Details: | |
NCBI Summary: | |
UniProt Code: | P06790 |
NCBI GenInfo Identifier: | 267290 |
NCBI Gene ID: | |
NCBI Accession: | P06790.2 |
UniProt Secondary Accession: | P06790 |
UniProt Related Accession: | P06790 |
Molecular Weight: | 43.3 kDa |
NCBI Full Name: | Regulatory protein E2 |
NCBI Synonym Full Names: | |
NCBI Official Symbol: | |
NCBI Official Synonym Symbols: | |
NCBI Protein Information: | |
UniProt Protein Name: | Regulatory protein E2 |
UniProt Synonym Protein Names: | |
Protein Family: | Regulatory protein |
UniProt Gene Name: | E2Â Â |
UniProt Entry Name: | VE2_HPV18 |