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Anti-EBAG9 Antibody (CAB1935)

SKU:
CAB1935
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Death
  • Cell Death Antibodies 1 Anti-EBAG9 Antibody CAB1935
  • Cell Death Antibodies 1 Anti-EBAG9 Antibody CAB1935
€139 - €419
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Description

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Antibody Name:Anti-EBAG9 Antibody
Antibody SKU:CAB1935
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 28-213 of human EBAG9 (NP_004206.1).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse
Positive Samples:Mouse kidney, Mouse liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 28-213 of human EBAG9 (NP_004206.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:RSGR GRKL SGDQ ITLP TTVD YSSV PKQT DVEE WTSW DEDA PTSV KIEG GNGN VATQ QNSL EQLE PDYF KDMT PTIR KTQK IVIK KREP LNFG IPDG STGF SSRL AATQ DLPF IHQS SELG DLDT WQEN TNAW EEEE DAAW QAEE VLRQ QKLA DREK RAAE QQRK KMEK EAQR LMKK EQNK IGVK LS
Gene ID:9166
Uniprot:O00559
Cellular Location:Golgi apparatus membrane, Single-pass type III membrane protein
Calculated MW:24kDa/29kDa
Observed MW:28kDa
Synonyms:EBAG9, EB9, PDAF
Background:This gene was identified as an estrogen-responsive gene. Regulation of transcription by estrogen is mediated by estrogen receptor, which binds to the estrogen-responsive element found in the 5'-flanking region of this gene. The encoded protein is a tumor-associated antigen that is expressed at high frequency in a variety of cancers. Alternate splicing results in multiple transcript variants. A pseudogene of this gene has been defined on chromosome 10.
UniProt Protein Function:RCAS1: May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1- beta converting enzyme (ICE)-like proteases. Homodimer. By estrogen. Widely expressed. Expressed in ovary, testis, prostate, thymus, muscle and heart, but not in small intestine, colon, lymph nodes, or peripherical blood lymphocytes. The protein is not detected in any of the above organs.
UniProt Protein Details:

Protein type:Membrane protein, integral; Apoptosis

Chromosomal Location of Human Ortholog: 8q23

Cellular Component: Golgi membrane; Golgi apparatus; focal adhesion; plasma membrane; integral to membrane; secretory granule

Molecular Function:apoptotic protease activator activity

Biological Process: apoptosis; regulation of cell growth

UniProt Code:O00559
NCBI GenInfo Identifier:8928283
NCBI Gene ID:
NCBI Accession:O00559.1
Molecular Weight:
NCBI Full Name:Receptor-binding cancer antigen expressed on SiSo cells
UniProt Protein Name:Receptor-binding cancer antigen expressed on SiSo cells
UniProt Synonym Protein Names:Cancer-associated surface antigen RCAS1; Estrogen receptor-binding fragment-associated gene 9 protein
Protein Family:Receptor-binding cancer antigen
UniProt Gene Name:EBAG9  
UniProt Entry Name:RCAS1_HUMAN
Anti-EBAG9 Antibody (CAB1935)Western blot analysis of extracts of various cell lines, using EBAG9 antibody (CAB1935) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST.
Anti-EBAG9 Antibody (CAB1935)Immunohistochemistry of paraffin-embedded human breast cancer using EBAG9 Antibody (CAB1935) at dilution of 1:100 (40x lens).

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