Efgitasialase alfa (Research-Grade) is a research-grade biosimilar antibody targeting sialidase-2. Reactivity: Human. Supplied as a liquid. Applications: ELISA, functional assays and in vivo research. Endotoxin: < 10 EU/mg. Purity: >95% as determined by SDS-PAGE. For research use only.
Sialidase-2 is a ~42 kDa protein. Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosacharides. Recognizes sialyl linkage positions of the glycan moiety as well as the supramolecular organization of the sialoglycoconjugate. Displays preference for alpha-(2->3)-sialylated GD1a and GT1B gangliosides over alpha-(2->8)-sialylated GD1b, in both monomeric forms and micelles. Hydrolyzes monomeric GM1 ganglioside, but has no activity toward the miscellar form. Has lower sialidase activity for glycoproteins such as fetuin and TF/transferrin that carry a mixture of alpha-(2->3) and alpha-(2->6)-sialyl linkages.
Product Name:
Efgitasialase alfa (Research-Grade)
SKU:
GXBS02625
Size:
100 µg, 1 mg
Target:
sialidase-2
Reactivity:
Human
Applications:
ELISA, Functional assay, Research in vivo
Synonyms:
2891502-37-5
Purity:
>95% as determined by SDS-PAGE.
Endotoxin Level:
< 10 EU/mg
State of Matter:
Liquid
Regulatory Status:
For research use only. Not suitable for clinical or therapeutic use.
Storage and Handling:
Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Chimeric IgG4-kappa anti-(human complement C3d) fused at the C-terminus of the heavy chain, via a (G4S)2 peptide linker to human complement factor H fragment.
