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[KO Validated] EGFR Rabbit Polyclonal Antibody (CAB2069)

SKU:
CAB2069
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Immunology
  • KO Validated Antibodies 1 Anti-EGFR Antibody CAB2069KO Validated
  • KO Validated Antibodies 1 Anti-EGFR Antibody CAB2069KO Validated
€139 - €419
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Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:[KO Validated] EGFR Rabbit Polyclonal Antibody
SKU:CAB2069
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1100-1200 of human EGFR (NP_005219.2).
Sequence:RPAG SVQN PVYH NQPL NPAP SRDP HYQD PHST AVGN PEYL NTVQ PTCV NSTF DSPA HWAQ KGSH QISL DNPD YQQD FFPK EAKP NGIF KGST AENA EYLR V
Tested Applications:WB IP ELISA
Recommended Dilution:WB,1:500 - 1:1000 IP,0.5μg-4μg antibody for 400μg-800μg extracts of whole cells
Synonyms:ERBB; ERRP; HER1; mENA; ERBB1; PIG61; NISBD2; EGFR
Positive Sample:HeLa, Mouse liver,Rat brain,Rat liver,Rat liver,Rat liver
Conjugate:Unconjugated
Cellular Localization:Cell membrane, Endoplasmic reticulum membrane, Endosome, Endosome membrane, Golgi apparatus membrane, Nucleus membrane, Nucleus, Secreted, Single-pass type I membrane protein.
Calculated MW:134kDa
Observed MW:175kDa//175kDa/175kDa

The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor, thus inducing receptor dimerization and tyrosine autophosphorylation leading to cell proliferation. Mutations in this gene are associated with lung cancer. EGFR is a component of the cytokine storm which contributes to a severe form of Coronavirus Disease 2019 (COVID-19) resulting from infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2).

Purification Method:Affinity purification
Gene ID:1956
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates using EGFR Rabbit pAb (CAB2069) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.

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