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[KO Validated] EGFR Rabbit Polyclonal Antibody (CAB11577)

SKU:
CAB11577
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology
  • KO Validated Antibodies 1 Anti-EGFR Antibody CAB11577KO Validated
  • KO Validated Antibodies 1 Anti-EGFR Antibody CAB11577KO Validated
  • KO Validated Antibodies 1 Anti-EGFR Antibody CAB11577KO Validated
  • KO Validated Antibodies 1 Anti-EGFR Antibody CAB11577KO Validated
  • KO Validated Antibodies 1 Anti-EGFR Antibody CAB11577KO Validated
€139 - €419
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Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:[KO Validated] EGFR Rabbit Polyclonal Antibody
SKU:CAB11577
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1021-1210 of human EGFR (NP_005219.2).
Sequence:QGFF SSPS TSRT PLLS SLSA TSNN STVA CIDR NGLQ SCPI KEDS FLQR YSSD PTGA LTED SIDD TFLP VPEY INQS VPKR PAGS VQNP VYHN QPLN PAPS RDPH YQDP HSTA VGNP EYLN TVQP TCVN STFD SPAH WAQK GSHQ ISLD NPDY QQDF FPKE AKPN GIFK GSTA ENAE YLRV APQS SEFI GA
Tested Applications:WB IHC-P IF/ICC ELISA
Recommended Dilution:WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200
Synonyms:ERBB; ERRP; HER1; mENA; ERBB1; PIG61; NISBD2; FR
Positive Sample:HeLa
Conjugate:Unconjugated
Cellular Localization:Cell membrane, Endoplasmic reticulum membrane, Endosome, Endosome membrane, Golgi apparatus membrane, Nucleus membrane, Nucleus, Secreted, Single-pass type I membrane protein.
Calculated MW:134kDa
Observed MW:175kDa

The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor, thus inducing receptor dimerization and tyrosine autophosphorylation leading to cell proliferation. Mutations in this gene are associated with lung cancer. EGFR is a component of the cytokine storm which contributes to a severe form of Coronavirus Disease 2019 (COVID-19) resulting from infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2).

Purification Method:Affinity purification
Gene ID:1956
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Product ImageWestern blot analysis of lysates from wild type(WT) and EGFR knockdown (KD) HeLa cells, using [KD Validated] EGFR Rabbit pAb (CAB11577) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 0.5s.

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