EGLN1/EGLN2 Rabbit Polyclonal Antibody (CAB10342)
- SKU:
- CAB10342
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | EGLN1/EGLN2 Rabbit Polyclonal Antibody |
SKU: | CAB10342 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 250-350 of human EGLN1/EGLN2 (NP_071334.1/NP_444274.1). |
Sequence: | DIRG DKIT WIEG KEPG CETI GLLM SSMD DLIR HCNG KLGS YKIN GRTK AMVA CYPG NGTG YVRH VDNP NGDG RCVT CIYY LNKD WDAK VSGG ILRI FPEG K |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | EGLN1/EGLN2 |
Positive Sample: | HL-60,293T |
Conjugate: | Unconjugated |
Cellular Localization: | cytoplasm, cytosol, glutamatergic synapse, nucleus, postsynaptic density |
Calculated MW: | 36kDa/43kDa/46kDa/40kDa |
Observed MW: | 44kDa |
The proteins encoded by EGLN1/EGLN2 gene catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. HIF is a transcriptional complex that plays a central role in mammalian oxygen homeostasis. This protein functions as a cellular oxygen sensor, and under normal oxygen concentration, modification by prolyl hydroxylation is a key regulatory event that targets HIF subunits for proteasomal destruction via the von Hippel-Lindau ubiquitylation complex.
Purification Method: | Affinity purification |
Gene ID: | 54583/112398 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |