Description
ETV6 Transcription Factor Activity Assay
The ETV6 Transcription Factor Activity Assay offered by AssayGenie is a highly sensitive and reliable kit designed for the detection and measurement of ETV6 transcription factor activity in cell lysates. This kit provides accurate results and is ideal for researchers studying the transcriptional regulation of ETV6, a critical factor involved in various cellular processes such as cell proliferation, differentiation, and apoptosis.ETV6, also known as TEL, is a transcriptional repressor that plays a crucial role in hematopoiesis and development.
Dysregulation of ETV6 has been implicated in various malignancies, including leukemia and solid tumors, making it a valuable target for cancer research and drug development.With its user-friendly protocol and high specificity, the ETV6 Transcription Factor Activity Assay kit is a valuable tool for understanding the role of ETV6 in normal and disease states, providing researchers with accurate and reproducible data for their studies.
| Product Name: | ETV6 Transcription Factor Activity Assay |
| Product Code: | TFAB00100 |
| Target: | ETV6 |
| Synonyms: | ETS translocation variant 6, ETS-related protein Tel1, Tel |
| Reactivity: | Human, Mouse, Rat |
| Sample Types: | Nuclear or cell lysates |
The Assay Genie ETV6 transcription factor activity assay allows for the detection and qualitative analysis of endogenous levels of activated transcription factors in a variety of nuclear and cell lysates
Assay Genie ELISA kits are designed to significantly reduce experiment time and ensure sensitivity and flexibility for high-throughput screening.
| Assay Time: | 4.5 hours |
| Detection Method: | Colorimetric 450 nm |
| Size: | 12 x 8-Well Microstrips |
| Storage: | 4°C for 6 months |
| UniProt Protein Function: | Tel: Transcriptional repressor; binds to the DNA sequence 5'- CCGGAAGT-3'. A chromosomal aberration involving ETV6 is found in a form of chronic myelomonocytic leukemia (CMML). Translocation t(5;12)(q33;p13) with PDGFRB. It is characterized by abnormal clonal myeloid proliferation and by progression to acute myelogenous leukemia (AML). Chromosomal aberrations involving ETV6 are found in a form of acute myeloid leukemia (AML). Translocation t(12;22)(p13;q11) with MN1; translocation t(4;12)(q12;p13) with CHIC2. Chromosomal aberrations involving ETV6 are found in childhood acute lymphoblastic leukemia (ALL). Translocations t(12;21)(p12;q22) and t(12;21)(p13;q22) with RUNX1/AML1. A chromosomal aberration involving ETV6 is found in a form of pre-B acute myeloid leukemia. Translocation t(9;12)(p24;p13) with JAK2. A chromosomal aberration involving ETV6 is found in myelodysplastic syndrome (MDS) with basophilia. Translocation t(5;12)(q31;p13) with ACSL6. A chromosomal aberration involving ETV6 is found in acute eosinophilic leukemia (AEL). Translocation t(5;12)(q31;p13) with ACSL6. A chromosomal aberration involving ETV6 is found in myelodysplastic syndrome (MDS). Translocation t(1;12)(p36.1;p13) with MDS2. Defects in ETV6 are a cause of myeloproliferative disorder chronic with eosinophilia (MPE). A hematologic disorder characterized by malignant eosinophils proliferation. A chromosomal aberration involving ETV6 is found in many instances of myeloproliferative disorder chronic with eosinophilia. Translocation t(5;12) with PDGFRB on chromosome 5 creating an ETV6-PDGFRB fusion protein. Defects in ETV6 are a cause of acute myelogenous leukemia (AML). AML is a malignant disease in which hematopoietic precursors are arrested in an early stage of development. A chromosomal aberration involving ETV6 is found in acute lymphoblastic leukemia. Translocation t(9;12)(p13;p13) with PAX5. Belongs to the ETS family. |
| UniProt Protein Details: | Protein type:Transcription factor; Oncoprotein; Motility/polarity/chemotaxis; DNA-binding Chromosomal Location of Human Ortholog: 12p13 Cellular Component: cytoplasm; nucleolus; nucleus Molecular Function:protein binding; protein domain specific binding; transcription factor activity Biological Process: cell differentiation; negative regulation of transcription from RNA polymerase II promoter Disease: Thrombocytopenia 5 |
| NCBI Summary: | This gene encodes an ETS family transcription factor. The product of this gene contains two functional domains: a N-terminal pointed (PNT) domain that is involved in protein-protein interactions with itself and other proteins, and a C-terminal DNA-binding domain. Gene knockout studies in mice suggest that it is required for hematopoiesis and maintenance of the developing vascular network. This gene is known to be involved in a large number of chromosomal rearrangements associated with leukemia and congenital fibrosarcoma. [provided by RefSeq, Sep 2008] |
| UniProt Code: | P41212 |
| NCBI GenInfo Identifier: | 730927 |
| NCBI Gene ID: | 2120 |
| NCBI Accession: | P41212.1 |
| UniProt Secondary Accession: | P41212,Q9UMF6, Q9UMF7, Q9UMG0, A3QVP6, A8K076, |
| UniProt Related Accession: | P41212 |
| Molecular Weight: | 53,000 Da |
| NCBI Full Name: | Transcription factor ETV6 |
| NCBI Synonym Full Names: | ETS variant 6 |
| NCBI Official Symbol: | ETV6 |
| NCBI Official Synonym Symbols: | TEL; THC5; TEL/ABL |
| NCBI Protein Information: | transcription factor ETV6 |
| UniProt Protein Name: | Transcription factor ETV6 |
| UniProt Synonym Protein Names: | ETS translocation variant 6; ETS-related protein Tel1; Tel |
| Protein Family: | Transcription factor |
| UniProt Gene Name: | ETV6 |
| UniProt Entry Name: | ETV6_HUMAN |
