Anti-FANCC Antibody (CAB1812)

Antibody Name:	Anti-FANCC Antibody
Antibody SKU:	CAB1812
Antibody Size:	20uL, 50uL, 100uL
Application:	WB IHC IF
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 319-558 of human FANCC (NP_000127.2).

Application:	WB IHC IF
Recommended Dilution:	WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:	Human, Mouse, Rat
Positive Samples:	HepG2, Jurkat, HeLa, Raji, Mouse small intestine

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 319-558 of human FANCC (NP_000127.2).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	TQCF VEAL EKAS KQLR FALK TYFP YTSP SLAM VLLQ DPQD IPRG HWLQ TLKH ISEL LREA VEDQ THGS CGGP FESW FLFI HFGG WAEM VAEQ LLMS AAEP PTAL LWLL AFYY GPRD GRQQ RAQT MVQV KAVL GHLL AMSR SSSL SAQD LQTV AGQG TDTD LRAP AQQL IRHL LLNF LLWA PGGH TIAW DVIT LMAH TAEI THEI IGFL DQTL YRWN RLGI ESPR SEKL AREL LKEL RTQV
Gene ID:	2176
Uniprot:	Q00597
Cellular Location:	Cytoplasm, Nucleus
Calculated MW:	63kDa
Observed MW:	65kDa

Synonyms:

FANCC, FA3, FAC, FACC

Background:

The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group C.

UniProt Protein Function:	FANCC: DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1. Defects in FANCC are the cause of Fanconi anemia complementation group C (FANCC). A disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair.
UniProt Protein Details:	Chromosomal Location of Human Ortholog: 9q22.3 Cellular Component: nucleoplasm; cytoplasm; nucleus; cytosol Molecular Function:protein binding Biological Process: removal of superoxide radicals; nucleotide-excision repair; myeloid cell homeostasis; protein complex assembly; DNA repair; germ cell development Disease: Fanconi Anemia, Complementation Group C; Tracheoesophageal Fistula With Or Without Esophageal Atresia
NCBI Summary:	The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group C. [provided by RefSeq, Jul 2008]
UniProt Code:	Q00597
NCBI GenInfo Identifier:	1706762
NCBI Gene ID:	2176
NCBI Accession:	Q00597.1
UniProt Secondary Accession:	Q00597,B1ALR8,
UniProt Related Accession:	Q00597
Molecular Weight:	558
NCBI Full Name:	Fanconi anemia group C protein
NCBI Synonym Full Names:	Fanconi anemia, complementation group C
NCBI Official Symbol:	FANCC
NCBI Official Synonym Symbols:	FA3; FAC; FACC
NCBI Protein Information:	Fanconi anemia group C protein
UniProt Protein Name:	Fanconi anemia group C protein
Protein Family:	Fanconi anemia group C protein
UniProt Gene Name:	FANCC
UniProt Entry Name:	FANCC_HUMAN

	Western blot analysis of extracts of various cell lines, using FANCC antibody (CAB1812) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST.
	Immunofluorescence analysis of U2OS cells using FANCC antibody (CAB1812). Blue: DAPI for nuclear staining.

Antibodies

FANCC Antibody (PACO09227)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)