FOXC1/2 Transcription Factor Activity Assay
- SKU:
- TFAB00108
- Product Type:
- ELISA Kit
- ELISA Type:
- Transcription Factor Assay
- Analytes:
- FOXC1/2
- Reactivity:
- Human
- Mouse
- Rat
Description
| Product Name: | FOXC1/2 Transcription Factor Activity Assay |
| Product Code: | TFAB00108 |
| Target: | FOXC1/2 |
| Synonyms: | Forkhead-related protein FKHL7, Forkhead-related transcription factor 3, FREAC-3 |
| Reactivity: | Human, Mouse, Rat |
| Sample Types: | Nuclear or cell lysates |
The Assay Genie FOXC1/2 transcription factor activity assay allows for the detection and qualitative analysis of endogenous levels of activated transcription factors in a variety of nuclear and cell lysates
Assay Genie ELISA kits are designed to significantly reduce experiment time and ensure sensitivity and flexibility for high-throughput screening.
| Assay Time: | 4.5 hours |
| Detection Method: | Colorimetric 450 nm |
| Size: | 12 x 8-Well Microstrips |
| Storage: | 4°C for 6 months |
| UniProt Protein Function: | FOXC1: Binding of FREAC-3 and FREAC-4 to their cognate sites results in bending of the DNA at an angle of 80-90 degrees. Monomer. Expressed in all tissues and cell lines examined. |
| UniProt Protein Details: | Protein type:Transcription factor; DNA-binding; Cell cycle regulation; Cell development/differentiation Chromosomal Location of Human Ortholog: 6p25 Cellular Component: cytoplasm; nuclear heterochromatin; nucleoplasm; nucleus Molecular Function:DNA bending activity; DNA binding; protein binding; sequence-specific DNA binding; transcription factor activity; transcription factor binding Biological Process: cell migration; cell proliferation; eye development; heart development; mesenchymal cell development; negative regulation of angiogenesis; negative regulation of mitotic cell cycle; odontogenesis of dentine-containing teeth; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of transcription, DNA-dependent Disease: Axenfeld-rieger Syndrome, Type 3; Iridogoniodysgenesis, Type 1 |
| NCBI Summary: | This gene belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. The specific function of this gene has not yet been determined; however, it has been shown to play a role in the regulation of embryonic and ocular development. Mutations in this gene cause various glaucoma phenotypes including primary congenital glaucoma, autosomal dominant iridogoniodysgenesis anomaly, and Axenfeld-Rieger anomaly. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q12948 |
| NCBI GenInfo Identifier: | 13638267 |
| NCBI Gene ID: | 2296 |
| NCBI Accession: | Q12948.3 |
| UniProt Secondary Accession: | Q12948,Q86UP7, Q9BYM1, Q9NUE5, Q9UDD0, Q9UP06, |
| UniProt Related Accession: | Q12948 |
| Molecular Weight: | 56,789 Da |
| NCBI Full Name: | Forkhead box protein C1 |
| NCBI Synonym Full Names: | forkhead box C1 |
| NCBI Official Symbol: | FOXC1Â Â |
| NCBI Official Synonym Symbols: | ARA; IGDA; IHG1; FKHL7; IRID1; RIEG3; FREAC3; FREAC-3Â Â |
| NCBI Protein Information: | forkhead box protein C1 |
| UniProt Protein Name: | Forkhead box protein C1 |
| UniProt Synonym Protein Names: | Forkhead-related protein FKHL7; Forkhead-related transcription factor 3; FREAC-3 |
| Protein Family: | Forkhead box protein |
| UniProt Gene Name: | FOXC1Â Â |
| UniProt Entry Name: | FOXC1_HUMAN |
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