Description
FOXC1/2 Transcription Factor Activity Assay
The FOX C1/2 Transcription Factor Activity Assay kit is a robust and reliable tool for studying the activity of FOX C1 and FOX C2 transcription factors in biological samples. These transcription factors play a critical role in regulating gene expression, cell differentiation, and development.This assay kit offers high sensitivity and specificity, allowing for accurate quantification of FOX C1 and FOX C2 activity in cells and tissues. By studying the activity of these transcription factors, researchers can gain valuable insights into the molecular mechanisms underlying various diseases, including cancer, neurodevelopmental disorders, and cardiovascular diseases.
With easy-to-follow protocols and quick assay turnaround times, the FOX C1/2 Transcription Factor Activity Assay kit is an essential tool for researchers looking to investigate the role of FOX C1 and FOX C2 in gene regulation and cellular processes.
| Product Name: | FOXC1/2 Transcription Factor Activity Assay |
| Product Code: | TFAB00108 |
| Target: | FOXC1/2 |
| Synonyms: | Forkhead-related protein FKHL7, Forkhead-related transcription factor 3, FREAC-3 |
| Reactivity: | Human, Mouse, Rat |
| Sample Types: | Nuclear or cell lysates |
The Assay Genie FOXC1/2 transcription factor activity assay allows for the detection and qualitative analysis of endogenous levels of activated transcription factors in a variety of nuclear and cell lysates
Assay Genie ELISA kits are designed to significantly reduce experiment time and ensure sensitivity and flexibility for high-throughput screening.
| Assay Time: | 4.5 hours |
| Detection Method: | Colorimetric 450 nm |
| Size: | 12 x 8-Well Microstrips |
| Storage: | 4°C for 6 months |
| UniProt Protein Function: | FOXC1: Binding of FREAC-3 and FREAC-4 to their cognate sites results in bending of the DNA at an angle of 80-90 degrees. Monomer. Expressed in all tissues and cell lines examined. |
| UniProt Protein Details: | Protein type:Transcription factor; DNA-binding; Cell cycle regulation; Cell development/differentiation Chromosomal Location of Human Ortholog: 6p25 Cellular Component: cytoplasm; nuclear heterochromatin; nucleoplasm; nucleus Molecular Function:DNA bending activity; DNA binding; protein binding; sequence-specific DNA binding; transcription factor activity; transcription factor binding Biological Process: cell migration; cell proliferation; eye development; heart development; mesenchymal cell development; negative regulation of angiogenesis; negative regulation of mitotic cell cycle; odontogenesis of dentine-containing teeth; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of transcription, DNA-dependent Disease: Axenfeld-rieger Syndrome, Type 3; Iridogoniodysgenesis, Type 1 |
| NCBI Summary: | This gene belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. The specific function of this gene has not yet been determined; however, it has been shown to play a role in the regulation of embryonic and ocular development. Mutations in this gene cause various glaucoma phenotypes including primary congenital glaucoma, autosomal dominant iridogoniodysgenesis anomaly, and Axenfeld-Rieger anomaly. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q12948 |
| NCBI GenInfo Identifier: | 13638267 |
| NCBI Gene ID: | 2296 |
| NCBI Accession: | Q12948.3 |
| UniProt Secondary Accession: | Q12948,Q86UP7, Q9BYM1, Q9NUE5, Q9UDD0, Q9UP06, |
| UniProt Related Accession: | Q12948 |
| Molecular Weight: | 56,789 Da |
| NCBI Full Name: | Forkhead box protein C1 |
| NCBI Synonym Full Names: | forkhead box C1 |
| NCBI Official Symbol: | FOXC1 |
| NCBI Official Synonym Symbols: | ARA; IGDA; IHG1; FKHL7; IRID1; RIEG3; FREAC3; FREAC-3 |
| NCBI Protein Information: | forkhead box protein C1 |
| UniProt Protein Name: | Forkhead box protein C1 |
| UniProt Synonym Protein Names: | Forkhead-related protein FKHL7; Forkhead-related transcription factor 3; FREAC-3 |
| Protein Family: | Forkhead box protein |
| UniProt Gene Name: | FOXC1 |
| UniProt Entry Name: | FOXC1_HUMAN |
