GCH1 Rabbit Polyclonal Antibody (CAB10616)
- SKU:
- CAB10616
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
Product Name: | GCH1 Rabbit Polyclonal Antibody |
SKU: | CAB10616 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 55-250 of human GCH1 (NP_000152.1). |
Sequence: | GERP RSEE DNEL NLPN LAAA YSSI LSSL GENP QRQG LLKT PWRA ASAM QFFT KGYQ ETIS DVLN DAIF DEDH DEMV IVKD IDMF SMCE HHLV PFVG KVHI GYLP NKQV LGLS KLAR IVEI YSRR LQVQ ERLT KQIA VAIT EALR PAGV GVVV EATH MCMV MRGV QKMN SKTV TSTM LGVF REDP KTRE EFLT LIRS |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200 |
Synonyms: | GCH; DYT5; DYT14; DYT5a; GTPCH1; HPABH4B; GTP-CH-1; GCH1 |
Positive Sample: | Mouse liver,Rat liver |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Nucleus. |
Calculated MW: | 28kDa |
Observed MW: | 28kDa |
This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described; however, not all variants give rise to a functional enzyme.
Purification Method: | Affinity purification |
Gene ID: | 2643 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |