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Metabolism Antibodies 3 Anti-HMBS Antibody CAB11701
Key Features

HMBS Rabbit Monoclonal Antibody (CAB11701)

Datasheet MSDS
SKU CAB11701
Product Type Antibody
Antibody Type Monoclonal Antibody
Reactivity Human, Mouse, Rat
Host Species Rabbit
Synonyms UPS, PBGD, PORC, PBG-D, HMBS
Research Use Metabolism
€131 - €457

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Description

system_update_altDatasheetsystem_update_altMSDS

HMBS Monoclonal Antibody (CAB11701)

The HMBS Monoclonal Antibody (CAB11701) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, developed from rabbit monoclonal cells, exhibits high reactivity with human samples and is validated for use in various applications such as Western blot and immunohistochemistry.HMBS, also known as hydroxymethylbilane synthase, plays a crucial role in the production of heme, a vital component of hemoglobin and other hemoproteins. Dysregulation of HMBS activity has been implicated in various diseases including acute intermittent porphyria.

This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.

Product Name:HMBS Monoclonal Antibody
SKU:CAB11701
Size:20μL, 100μL
Reactivity:Human, Mouse, Rat
Clone Number:ARC0685
Conjugate:Unconjugated
Immunogen:Synthetic peptide. This information is considered to be commercially sensitive.
Sequence:ERAF LRHL EGGC SVPV AVHT AMKD GQLY LTGG VWSL DGSD SIQE TMQA TIHV PAQH EDGP EDDP QLVG ITAR NIPR GPQL AAQN LGIS LANL LLSK GAKN I
Tested Applications:WB ELISA
Recommended Dilution:
WB1:500 - 1:2000
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:UPS, PBGD, PORC, PBG-D, HMBS
Positive Sample:Hep G2, Mouse kidney, Mouse heart, Rat kidney
Cellular Localization:Cytoplasm.
Calculated MW:39kDa
Observed MW:45-50kDa

This gene encodes a member of the hydroxymethylbilane synthase superfamily. The encoded protein is the third enzyme of the heme biosynthetic pathway and catalyzes the head to tail condensation of four porphobilinogen molecules into the linear hydroxymethylbilane. Mutations in this gene are associated with the autosomal dominant disease acute intermittent porphyria. Alternatively spliced transcript variants encoding different isoforms have been described.

Purification MethodAffinity purification
Gene ID3145
RRIDAB_2861635
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide, pH 7.3.
Product ImageWestern blot analysis of various lysates using HMBS Rabbit mAb (CAB11701) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 3min.
Product ImageWestern blot analysis of various lysates using HMBS Rabbit mAb (CAB11701) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (AbGn00021). Exposure time: 3min.
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