Anti-HSC70 Interacting Protein HIP Antibody (CAB9567)

SKU:
CAB9567
€129 - €349

Description

Technical Manual

Anti-HSC70 Interacting Protein HIP Antibody

Product Name:Anti-HSC70 Interacting Protein HIP Antibody
Product SKU:CAB9567
Size:20uL, 50 uL
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Background:

The protein encoded by this gene is an adaptor protein that mediates the association of the heat shock proteins HSP70 and HSP90. This protein has been shown to be involved in the assembly process of glucocorticoid receptor, which requires the assistance of multiple molecular chaperones. The expression of this gene is reported to be downregulated in colorectal carcinoma tissue suggesting that it is a candidate tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013]

Immunogen:A synthesized peptide derived from human HSC70 Interacting Protein HIP
Sequence:

Email for sequence

Gene ID:6767
Swiss Prot:P50502
Synonyms:AAG2; FAM10A1; FAM10A4; HIP; HOP; HSPABP; HSPABP1; P48; PRO0786; SNC6
Calculated MW:47kDa
Observed MW:50KDa
Reactivity:Human, Mouse
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Application Key:Western blotting
Positive Samples:HeLa, 293T, NIH/3T3, Mouse brain, Mouse spleen
Cellular Location:

Product Images

Anti-HSC70 Interacting Protein HIP Antibody (CAB9567)

Western blot - HSC70 Interacting Protein HIP Rabbit mAb (CAB9567)

Uniprot Information

UniProt Protein Function:HIP: One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins. Homotetramer. Interacts with HSC70 as well as DNAJ homologs and HSP90. Interacts (via the C-terminus 303- 319 AA) with GRK5. Belongs to the FAM10 family.
UniProt Protein Details:

Protein type:Adaptor/scaffold

Chromosomal Location of Human Ortholog: 22q13.2

Cellular Component: protein complex; cytoplasm; cytosol

Molecular Function:protein binding, bridging; identical protein binding; protein domain specific binding; protein binding; chaperone binding; unfolded protein binding; protein complex binding; dATP binding; Hsp70 protein binding

Biological Process: protein folding; protein homooligomerization

NCBI Summary:The protein encoded by this gene is an adaptor protein that mediates the association of the heat shock proteins HSP70 and HSP90. This protein has been shown to be involved in the assembly process of glucocorticoid receptor, which requires the assistance of multiple molecular chaperones. The expression of this gene is reported to be downregulated in colorectal carcinoma tissue suggesting that it is a candidate tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013]
UniProt Code:P50502
NCBI GenInfo Identifier:6686278
NCBI Gene ID:6767
NCBI Accession:P50502.2
UniProt Secondary Accession:P50502,O14999, Q2TU77,
UniProt Related Accession:P50502
Molecular Weight:41,332 Da
NCBI Full Name:Hsc70-interacting protein
NCBI Synonym Full Names:suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
NCBI Official Symbol:ST13
NCBI Official Synonym Symbols:HIP; HOP; P48; AAG2; SNC6; HSPABP; FAM10A1; FAM10A4; HSPABP1; PRO0786
NCBI Protein Information:hsc70-interacting protein; Hsp70-interacting protein; aging-associated protein 2; putative tumor suppressor ST13; renal carcinoma antigen NY-REN-33; heat shock 70kD protein binding protein; suppression of tumorigenicity 13 protein; progesterone receptor-associated p48 protein
UniProt Protein Name:Hsc70-interacting protein
UniProt Synonym Protein Names:Aging-associated protein 2; Progesterone receptor-associated p48 protein; Protein FAM10A1; Putative tumor suppressor ST13; Renal carcinoma antigen NY-REN-33; Suppression of tumorigenicity 13 protein
Protein Family:Hsc70-interacting protein
UniProt Gene Name:ST13
UniProt Entry Name:F10A1_HUMAN
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Additional Information

Product type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Monoclonal Antibody
Research Area:
Cell Biology
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