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Anti-ST13 Antibody (CAB8454)

SKU:
CAB8454
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
€139 - €419
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Description

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Antibody Name:Anti-ST13 Antibody
Antibody SKU:CAB8454
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-369 of human ST13 (NP_003923.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:SW480, A-431, NIH/3T3, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-369 of human ST13 (NP_003923.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MDPR KVNE LRAF VKMC KQDP SVLH TEEM RFLR EWVE SMGG KVPP ATQK AKSE ENTK EEKP DSKK VEED LKAD EPSS EESD LEID KEGV IEPD TDAP QEMG DENA EITE EMMD QAND KKVA AIEA LNDG ELQK AIDL FTDA IKLN PRLA ILYA KRAS VFVK LQKP NAAI RDCD RAIE INPD SAQP YKWR GKAH RLLG HWEE AAHD LALA CKLD YDED ASAM LKEV QPRA QKIA EHRR KYER KREE REIK ERIE RVKK AREE HERA QREE EARR QSGA QYGS FPGG FPGG MPGN FPGG MPGM GGGM PGMA GMPG LNEI LSDP EVLA AMQD PEVM VAFQ DVAQ NPAN MSKY QSNP KVMN LISK LSAK FGGQ A
Gene ID:6767
Uniprot:P50502
Cellular Location:Cytoplasm
Calculated MW:41kDa
Observed MW:52kDa
Synonyms:ST13, AAG2, FAM10A1, FAM10A4, HIP, HOP, HSPABP, HSPABP1, P48, PRO0786, SNC6
Background:The protein encoded by this gene is an adaptor protein that mediates the association of the heat shock proteins HSP70 and HSP90. This protein has been shown to be involved in the assembly process of glucocorticoid receptor, which requires the assistance of multiple molecular chaperones. The expression of this gene is reported to be downregulated in colorectal carcinoma tissue suggesting that it is a candidate tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding different isoforms.
UniProt Protein Function:HIP: One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins. Homotetramer. Interacts with HSC70 as well as DNAJ homologs and HSP90. Interacts (via the C-terminus 303- 319 AA) with GRK5. Belongs to the FAM10 family.
UniProt Protein Details:

Protein type:Adaptor/scaffold

Chromosomal Location of Human Ortholog: 22q13.2

Cellular Component: protein complex; cytoplasm; cytosol

Molecular Function:protein binding, bridging; identical protein binding; protein domain specific binding; protein binding; chaperone binding; unfolded protein binding; protein complex binding; dATP binding; Hsp70 protein binding

Biological Process: protein folding; protein homooligomerization

NCBI Summary:The protein encoded by this gene is an adaptor protein that mediates the association of the heat shock proteins HSP70 and HSP90. This protein has been shown to be involved in the assembly process of glucocorticoid receptor, which requires the assistance of multiple molecular chaperones. The expression of this gene is reported to be downregulated in colorectal carcinoma tissue suggesting that it is a candidate tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013]
UniProt Code:P50502
NCBI GenInfo Identifier:6686278
NCBI Gene ID:6767
NCBI Accession:P50502.2
UniProt Secondary Accession:P50502,O14999, Q2TU77,
UniProt Related Accession:P50502
Molecular Weight:41,332 Da
NCBI Full Name:Hsc70-interacting protein
NCBI Synonym Full Names:suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
NCBI Official Symbol:ST13  
NCBI Official Synonym Symbols:HIP; HOP; P48; AAG2; SNC6; HSPABP; FAM10A1; FAM10A4; HSPABP1; PRO0786  
NCBI Protein Information:hsc70-interacting protein; Hsp70-interacting protein; aging-associated protein 2; putative tumor suppressor ST13; renal carcinoma antigen NY-REN-33; heat shock 70kD protein binding protein; suppression of tumorigenicity 13 protein; progesterone receptor-associated p48 protein
UniProt Protein Name:Hsc70-interacting protein
UniProt Synonym Protein Names:Aging-associated protein 2; Progesterone receptor-associated p48 protein; Protein FAM10A1; Putative tumor suppressor ST13; Renal carcinoma antigen NY-REN-33; Suppression of tumorigenicity 13 protein
Protein Family:Hsc70-interacting protein
UniProt Gene Name:ST13  
UniProt Entry Name:F10A1_HUMAN
Anti-ST13 Polyclonal Antibody (CAB8454)Western blot analysis of extracts of various cell lines, using ST13 antibody (CAB8454) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s.

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