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Human CD371/CLEC12A Antibody (H6e7) - SDS-PAGE
Key Features

Human CD371/CLEC12A Antibody (H6e7) (GXBS02134)

Datasheet MSDS
SKU GXBS02134
Product Type Research Grade Biosimilar
Antibody Type Monoclonal
Host Species Human
Reactivity Human
Applications ELISA, FCM, Functional assay, Research in vivo
Clone ID H6e7
Isotype IgG1
$677 - $2,208

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Description

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Human CD371/CLEC12A Antibody (H6e7)

Human CD371/CLEC12A Antibody (H6e7) is a research-grade biosimilar monoclonal antibody targeting CD371. It is a human IgG1 antibody. Reactivity: Human. Supplied as a liquid in 0.01M PBS pH 7.4. Applications: ELISA, flow cytometry, functional assays and in vivo research. Endotoxin: < 10 EU/mg. Purity: >95% purity as determined by SDS-PAGE. For research use only.

C-type lectin domain family 12 member A (CD371/CLEC12A) is a ~30 kDa protein. Myeloid inhibitory C-type lectin receptor that acts as a negative regulator of myeloid cell activation. Myeloid cell inhibition is required to limit proinflammatory pathways and protect against excessive inflammation. Specifically recognizes and binds various structures, such as neutrophil extracellular traps (NETs) or monosodium urate crystals. Also acts as a pattern-recognition receptor for pathogen-associated molecules, such as plasmodium hemozoin or mycobacterial micolic acid. Ligand-binding induces phosphorylation of its ITIM motif, followed by recruitment of tyrosine-protein phosphatases PTPN6 and PTPN11, which counteract tyrosine-protein kinase SYK, thereby preventing myeloid cell activation.

Product Name:Human CD371/CLEC12A Antibody (H6e7)
SKU:GXBS02134
Size:100 µg, 1 mg
Antibody Type:Monoclonal Antibody
Clone:H6e7
Target:CLEC12A
Isotype:IgG1
Host Species:Human
Reactivity:Human
Applications:ELISA, FCM, Functional assay, Research in vivo
Expression Host:Mammalian cells
Synonyms:CLEC12A, DCAL2, Dendritic cell-associated lectin 2, CLL-1, Myeloid inhibitory C-type lectin-like receptor, C-type lectin domain family 12 member A, CLL1, DCAL-2, C-type lectin-like molecule 1, MICL, CD371
Purity:>95% as determined by SDS-PAGE.
Endotoxin Level:< 10 EU/mg
Formulation:0.01M PBS pH 7.4.
State of Matter:Liquid
Regulatory Status:For research use only. Not suitable for clinical or therapeutic use.
Product Preparation:Protein A/G purified from cell culture supernatant.
Storage and Handling:Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
UniProt:Q5QGZ9
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