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Human DNA-binding protein Ikaros / IKZF1 ELISA Kit

SKU:
HUFI01303
Product Type:
ELISA Kit
Size:
96 Assays
Uniprot:
Q13422
Sensitivity:
0.094ng/ml
Range:
0.156-10ng/ml
ELISA Type:
Sandwich
Synonyms:
IKZF1, DNA-binding protein Ikaros, Ikaros family zinc finger protein 1, Lymphoid transcription factor LyF-1, IK1, IKAROS, LYF1, PRO0758, ZNFN1A1, hIk-1, ZNFN1A1CLL-associated antigen KW-6
Reactivity:
Human
Research Area:
Cell Cycle
€599
Frequently bought together:

Description

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Human DNA-binding protein Ikaros / IKZF1 ELISA Kit

DNA-binding protein Ikaros/IKZF1 codes for a transcription factor that is part of the zinc-finger DNA-binding protein family that is involved in chromatin remodelling. DNA-binding protein Ikaros/IKZF1 is only found in the foetal and adult hemo-lymphopoietic systems, and it works as a lymphocyte differentiation regulator. The number of N-terminal zinc finger motifs that bind DNA and the presence of a nuclear localization signal change between isoforms, resulting in members with and without DNA-binding characteristics. Only a few isoforms have the three or more N-terminal zinc motifs required for high affinity binding to a particular core DNA sequence region in target gene promoters. B-cell cancers, such as acute lymphoblastic leukaemia, have been linked to overexpression of several dominant-negative isoforms. Immunodeficiency, Common Variable 13, and Diamond-Blackfan Anemia-Like are diseases linked to IKZF1.