Description
Human GRB10 Recombinant Protein (N-His)
Human GRB10 Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Thr392-Leu594, with an N-terminal His tag. Predicted molecular weight: 25.49 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Growth factor receptor-bound protein 10 (GRB10) is a ~67 kDa protein. Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. For research use only.
Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation.
| Product Name: | Human GRB10 Recombinant Protein (N-His) |
| SKU: | GXRP02187 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | GRB10 adapter protein, Growth factor receptor-bound protein 10, KIAA0207, Insulin receptor-binding protein Grb-IR, GRB10, GRBIR |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Thr392-Leu594 |
| Calculated MW: | 25.49 kDa |
| UniProt: | Q13322 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only. |
