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Anti-IKZF3 Antibody (CAB7287)

SKU:
CAB7287
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology
  • Immunology Antibodies 2 Anti-IKZF3 Antibody CAB7287
  • Immunology Antibodies 2 Anti-IKZF3 Antibody CAB7287
€139 - €419
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Description

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Antibody Name:Anti-IKZF3 Antibody
Antibody SKU:CAB7287
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 280-450 of human IKZF3 (NP_036613.2).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:100
Reactivity:Human, Mouse
Positive Samples:BT-474, Mouse thymus
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 280-450 of human IKZF3 (NP_036613.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:HCFD VNYN SSYM YEKE SELI QTRM MDQA INNA ISYL GAEA LRPL VQTP PAPT SEMV PVIS SMYP IALT RAEM SNGA PQEL EKKS IHLP EKSV PSER GLSP NNSG HDST DTDS NHEE RQNH IYQQ NHMV LSRA RNGM PLLK EVPR SYEL LKPP PICP RDSV KVIN KEGE VMD
Gene ID:22806
Uniprot:Q9UKT9
Cellular Location:Cytoplasm, Nucleus
Calculated MW:29-58kDa
Observed MW:58kDa
Synonyms:IKZF3, AIO, AIOLOS, ZNFN1A3
Background:This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described, as well as some non-protein coding variants.
UniProt Protein Function:Aiolos: a transcription factor of the ikaros C2H2-type zinc-finger protein family. Plays an important role in the regulation of lymphocyte differentiation. Deletions in Aiolos have been observed in a subset of pre-B-cell acute lymphoblastic leukemia (B-ALL) cases. 6 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:C2H2-type zinc finger protein; DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 17q21

Cellular Component: cytoplasm; plasma membrane; nucleus

Molecular Function:protein binding; protein homodimerization activity; protein heterodimerization activity; sequence-specific DNA binding; metal ion binding; transcription factor activity

Biological Process: regulation of apoptosis; regulation of transcription from RNA polymerase II promoter; B cell activation; transcription, DNA-dependent; regulation of lymphocyte differentiation; regulation of B cell differentiation; regulation of B cell proliferation; mesoderm development

NCBI Summary:This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described, as well as some non-protein coding variants. [provided by RefSeq, Apr 2012]
UniProt Code:Q9UKT9
NCBI GenInfo Identifier:212276437
NCBI Gene ID:22806
NCBI Accession:Q9UKT9.2
UniProt Secondary Accession:Q9UKT9,Q69BL6, Q69BL7, Q69BL8, Q69BL9, Q69BM0, Q69BM1 Q69BM2, Q69BM3, Q69BM5, Q8N574, B4DVV5,
UniProt Related Accession:Q9UKT9
Molecular Weight:509
NCBI Full Name:Zinc finger protein Aiolos
NCBI Synonym Full Names:IKAROS family zinc finger 3 (Aiolos)
NCBI Official Symbol:IKZF3  
NCBI Official Synonym Symbols:AIO; AIOLOS; ZNFN1A3  
NCBI Protein Information:zinc finger protein Aiolos; zinc finger DNA binding protein Aiolos; zinc finger protein, subfamily 1A, 3 (Aiolos)
UniProt Protein Name:Zinc finger protein Aiolos
UniProt Synonym Protein Names:Ikaros family zinc finger protein 3
Protein Family:Zinc finger protein
UniProt Gene Name:IKZF3  
UniProt Entry Name:IKZF3_HUMAN
Anti-IKZF3 Antibody (CAB7287)Western blot analysis of extracts of various cell lines, using IKZF3 Antibody (CAB7287) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
Anti-IKZF3 Antibody (CAB7287)Immunofluorescence analysis of MCF-7 cells using IKZF3 antibody (CAB7287). Blue: DAPI for nuclear staining.

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