K48-linkage Specific Ubiquitin Rabbit Monoclonal Antibody (CAB3606)
- SKU:
- CAB3606
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
Product Name: | K48-linkage Specific Ubiquitin Rabbit Monoclonal Antibody |
SKU: | CAB3606 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Ubiquitin (P0CG47). |
Sequence: | MQIF VKTL TGKT ITLE VEPS DTIE NVKA KIQD KEGI PPDQ QRLI FAGK QLED GRTL SDYN IQKE STLH LVLR LRGG MQIF VKTL TGKT ITLE VEPS DTIE |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200 |
Synonyms: | HEL-S-50; K48-linkage Specific Ubiquitin |
Positive Sample: | HeLa treated by MG132 |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Nucleus. |
Calculated MW: | 26kDa |
Observed MW: | 17-250kDa |
This gene encodes ubiquitin, one of the most conserved proteins known. Ubiquitin has a major role in targeting cellular proteins for degradation by the 26S proteosome. It is also involved in the maintenance of chromatin structure, the regulation of gene expression, and the stress response. Ubiquitin is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin moiety fused to an unrelated protein. This gene consists of three direct repeats of the ubiquitin coding sequence with no spacer sequence. Consequently, the protein is expressed as a polyubiquitin precursor with a final amino acid after the last repeat. An aberrant form of this protein has been detected in patients with Alzheimer's disease and Down syndrome. Pseudogenes of this gene are located on chromosomes 1, 2, 13, and 17. Alternative splicing results in multiple transcript variants.
Purification Method: | Affinity purification |
Gene ID: | 7314 |
Clone Number: | ARC0811 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |