null

Anti-KIFAP3 Antibody (CAB4518)

SKU:
CAB4518
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
KIFAP3
FLA3
KAP-1
KAP-3
KAP3
SMAP
Smg-GDS
dJ190I16.1
Research Area:
Cell Biology
  • Cell Biology Antibodies 9 Anti-KIFAP3 Antibody CAB4518
  • Cell Biology Antibodies 9 Anti-KIFAP3 Antibody CAB4518
  • Cell Biology Antibodies 9 Anti-KIFAP3 Antibody CAB4518
  • Cell Biology Antibodies 9 Anti-KIFAP3 Antibody CAB4518
  • Cell Biology Antibodies 9 Anti-KIFAP3 Antibody CAB4518
  • Cell Biology Antibodies 9 Anti-KIFAP3 Antibody CAB4518
€139 - €419
Frequently bought together:

Description

Product Name:KIFAP3 Rabbit pAb
Product Code:CAB4518
Size:20uL, 50uL, 100uL
Synonyms:KIFAP3, FLA3, KAP-1, KAP-3, KAP3, SMAP, Smg-GDS, dJ190I16.1
Applications:WB, IF, IP
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human KIFAP3 (NP_055785.2).
Applications:WB, IF, IP
Recommended Dilutions:WB 1:500 - 1:2000 IF 1:50 - 1:200 IP 1:50 - 1:100
Reactivity:Human, Mouse, Rat
Positive Samples:LO2, SH-SY5Y, Mouse brain, Mouse testis, Mouse lung, Rat lung
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human KIFAP3 (NP_055785.2).
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MQGE DARY LKRK VKGG NIDV HPSE KALI VHYE VEAT ILGE MGDP MLGE RKEC QKII RLKS LNAN TDIT SLAR KVVE ECKL IHPS KLNE VEQL LYYL QNRR DSLS GKEK KEKS SKPK DPPP FEGM EIDE VANI NDMD EYIE LLYE DIPD KVRG SALI LQLA RNPD NLEE LLLN ETAL GALA RVLR EDWK QSVE LATN IIYI
Gene ID:22920
Uniprot:Q92845
Calculated MW:82kDa/86kDa/91kDa
Observed MW:110kDa
UniProt Protein Function:KIFAP3: Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Binds to the tail domain of the KIF3A/KIF3B heterodimer to form a heterotrimeric KIF3 complex and may regulate the membrane binding of this complex.
UniProt Protein Details:

Protein type:Adaptor/scaffold

Chromosomal Location of Human Ortholog: 1q24.2

Cellular Component: microtubule cytoskeleton; Golgi apparatus; centrosome; condensed nuclear chromosome; endoplasmic reticulum; spindle microtubule; kinesin II complex; axoneme; cytosol; photoreceptor connecting cilium

Molecular Function:protein binding; kinesin binding

Biological Process: negative regulation of cell proliferation; protein localization; positive regulation of calcium-dependent cell-cell adhesion; organelle organization and biogenesis; antigen processing and presentation of exogenous peptide antigen via MHC class II; protein complex assembly; blood coagulation; signal transduction; microtubule-based movement; microtubule-based process; negative regulation of apoptosis

NCBI Summary:The small G protein GDP dissociation stimulator (smg GDS) is a regulator protein having two activities on a group of small G proteins including the Rho and Rap1 family members and Ki-Ras; one is to stimulate their GDP/GTP exchange reactions, and the other is to inhibit their interactions with membranes. The protein encoded by this gene contains 9 'Armadillo' repeats and interacts with the smg GDS protein through these repeats. This protein, which is highly concentrated around the endoplasmic reticulum, is phosphorylated by v-src, and this phosphorylation reduces the affinity of the protein for smg GDS. It is thought that this protein serves as a linker between human chromosome-associated polypeptide (HCAP) and KIF3A/B, a kinesin superfamily protein in the nucleus, and that it plays a role in the interaction of chromosomes with an ATPase motor protein. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
UniProt Code:Q92845
NCBI GenInfo Identifier:73920216
NCBI Gene ID:22920
NCBI Accession:Q92845.2
UniProt Secondary Accession:Q92845,Q8NHU7, Q9H416, B1AKU4, B1AKU5, B2RDL1, B7Z8A3 F5H591,
UniProt Related Accession:Q92845
Molecular Weight:792
NCBI Full Name:Kinesin-associated protein 3
NCBI Synonym Full Names:kinesin-associated protein 3
NCBI Official Symbol:KIFAP3  
NCBI Official Synonym Symbols:FLA3; KAP3; SMAP; KAP-1; KAP-3; Smg-GDS; dJ190I16.1  
NCBI Protein Information:kinesin-associated protein 3; smg GDS-associated protein; small G protein GDP dissociation stimulator
UniProt Protein Name:Kinesin-associated protein 3
UniProt Synonym Protein Names:Smg GDS-associated protein
Protein Family:Kinesin-associated protein
UniProt Gene Name:KIFAP3  
UniProt Entry Name:KIFA3_HUMAN

Related Products