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[KO Validated] NFKB1 Rabbit Polyclonal Antibody (CAB6667)

SKU:
CAB6667
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Death
  • KO Validated Antibodies 1 Anti-NFKB1 Antibody CAB6667KO Validated
  • KO Validated Antibodies 1 Anti-NFKB1 Antibody CAB6667KO Validated
  • KO Validated Antibodies 1 Anti-NFKB1 Antibody CAB6667KO Validated
  • KO Validated Antibodies 1 Anti-NFKB1 Antibody CAB6667KO Validated
€139 - €419
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Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:[KO Validated] NFKB1 Rabbit Polyclonal Antibody
SKU:CAB6667
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 41-365 of human NFKB1 (NP_001158884.1).
Sequence:GPYL QILE QPKQ RGFR FRYV CEGP SHGG LPGA SSEK NKKS YPQV KICN YVGP AKVI VQLV TNGK NIHL HAHS LVGK HCED GICT VTAG PKDM VVGF ANLG ILHV TKKK VFET LEAR MTEA CIRG YNPG LLVH PDLA YLQA EGGG DRQL GDRE KELI RQAA LQQT KEMD LSVV RLMF TAFL PDST GSFT RRLE PVVS DAIY DSKA PNAS NLKI VRMD RTAG CVTG GEEI YLLC DKVQ KDDI QIRF YEEE ENGG VWEG FGDF SPTD VHRQ FAIV FKTP KYKD INIT KPAS VFVQ LRRK SDLE TSEP KPFL YYPE IKDK EEVQ RKRQ K
Tested Applications:WB IHC-P IF/ICC ELISA
Recommended Dilution:WB,1:100 - 1:500 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200
Synonyms:KBF1; EBP-1; NF-kB; CVID12; NF-kB1; NFKB-p50; NFkappaB; NF-kappaB; NFKB-p105; NF-kappa-B1; NF-kappabeta; NFKB1
Positive Sample:Mouse lung
Conjugate:Unconjugated
Cellular Localization:Cytoplasm, Nucleus.
Calculated MW:105kDa
Observed MW:50kDa/120kDa

This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. NFKB is a critical regulator of the immediate-early response to viral infection. Alternative splicing results in multiple transcript variants encoding different isoforms, at least one of which is proteolytically processed.

Purification Method:Affinity purification
Gene ID:4790
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Product ImageWestern blot analysis of lysates from Mouse lung, using NFKB1 Rabbit pAb (CAB6667) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 20s.

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