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[KO Validated] p38 MAPK Rabbit Polyclonal Antibody (CAB14401)

SKU:
CAB14401
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Death
  • KO Validated Antibodies 1 Anti-p38 MAPK Antibody CAB14401KO Validated
  • KO Validated Antibodies 1 Anti-p38 MAPK Antibody CAB14401KO Validated
  • KO Validated Antibodies 1 Anti-p38 MAPK Antibody CAB14401KO Validated
  • KO Validated Antibodies 1 Anti-p38 MAPK Antibody CAB14401KO Validated
  • KO Validated Antibodies 1 Anti-p38 MAPK Antibody CAB14401KO Validated
€139 - €419
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Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:[KO Validated] p38 MAPK Rabbit Polyclonal Antibody
SKU:CAB14401
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 261-360 of human p38 MAPK (NP_620581.1).
Sequence:SLTQ MPKM NFAN VFIG ANPL AVDL LEKM LVLD SDKR ITAA QALA HAYF AQYH DPDD EPVA DPYD QSFE SRDL LIDE WKSL TYDE VISF VPPP LDQE EMES
Tested Applications:WB IHC-P IF/ICC IP ELISA
Recommended Dilution:WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:100 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells
Synonyms:RK; p38; CSBP; EXIP; Mxi2; CSBP1; CSBP2; CSPB1; PRKM14; PRKM15; SAPK2A; p38ALPHA; p38 MAPK
Positive Sample:HeLa,BxPC-3,Mouse testis,Rat kidney
Conjugate:Unconjugated
Cellular Localization:Cytoplasm, Nucleus.
Calculated MW:41kDa
Observed MW:41kDa

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Purification Method:Affinity purification
Gene ID:1432
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.09% Sodium azide,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates using p38 MAPK Rabbit pAb (CAB14401) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 30s.

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