MCM6 Rabbit Polyclonal Antibody (CAB1955)
- SKU:
- CAB1955
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Cycle
Description
Product Name: | MCM6 Rabbit Polyclonal Antibody |
SKU: | CAB1955 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 562-821 of human MCM6 (NP_005906.2). |
Sequence: | SIDR VYSL DDIR RYLL FARQ FKPK ISKE SEDF IVEQ YKHL RQRD GSGV TKSS WRIT VRQL ESMI RLSE AMAR MHCC DEVQ PKHV KEAF RLLN KSII RVET PDVN LDQE EEIQ MEVD EGAG GING HADS PAPV NGIN GYNE DINQ ESAP KASL RLGF SEYC RISN LIVL HLRK VEEE EDES ALKR SELV NWYL KEIE SEID SEEE LINK KRII EKVI HRLT HYDH VLIE LTQA GLKG STEG SESY EEDP YLVV NPNY LLED |
Tested Applications: | WB IF/ICC IP ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells |
Synonyms: | Mis5; P105MCM; MCG40308; MCM6 |
Positive Sample: | U-251MG,HeLa,MCF7,HL-60,NIH/3T3,Mouse spleen |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus. |
Calculated MW: | 93kDa |
Observed MW: | 110kDa |
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of the complex by CDC2 kinase reduces the helicase activity, suggesting a role in the regulation of DNA replication. Single nucleotide polymorphisms in the intron regions of this gene are associated with differential transcriptional activation of the promoter of the neighboring lactase gene and, thereby, influence lactose intolerance in early adulthood.
Purification Method: | Affinity purification |
Gene ID: | 4175 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |