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MEK5 Rabbit Monoclonal Antibody (CAB12457)

SKU:
CAB12457
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Monoclonal Antibody
Research Area:
Cell Biology
€139 - €419
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:MEK5 Rabbit Monoclonal Antibody
SKU:CAB12457
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 250-350 of human MEK5 (Q13163).
Sequence:DVYR KMPE HVLG RIAV AVVK GLTY LWSL KILH RDVK PSNM LVNT RGQV KLCD FGVS TQLV NSIA KTYV GTNA YMAP ERIS GEQY GIHS DVWS LGIS FMEL A
Tested Applications:WB ELISA
Recommended Dilution:WB,1:500 - 1:2000
Synonyms:MEK5
Positive Sample:Mouse testis,Rat liver,RD
Conjugate:Unconjugated
Cellular Localization:Cytosol, Nucleus, Spindle
Calculated MW:50kDa
Observed MW:50kDa

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been described.

Purification Method:Affinity purification
Gene ID:5607
Clone Number:ARC0711
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Product ImageWestern blot analysis of extracts of RD cells, using MEK5 Rabbit mAb (CAB12457) at 1：1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.

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