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Anti-Methylglyoxal Antibody [9E7]

Datasheet
SKU STMA00186
Antibody Type Monoclonal
Applications WB
Applications ICC/IF
Applications IHC
Applications FACS
Applications FCM
Applications ELISA
Reactivity Species Independent
Host Species Mouse
Isotype IgG2a
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Description

Methylglyoxal Antibody [9E7]

Methylglyoxal Antibody [9E7] is a mouse monoclonal antibody directed against Methylglyoxal, offered by Assay Genie for research applications. Reported applications include WB, ICC/IF, IHC, FACS, FCM and ELISA. Reactivity is species independent. Supplied as IgG2a, purified by Protein G.

Methylglyoxal (MG) is a highly reactive alpha-oxoaldehyde generated as a byproduct of glycolysis and lipid peroxidation. In the nervous system, MG contributes to oxidative stress by forming advanced glycation end products (AGEs) through reactions with amino acids and protein residues. These AGEs disrupt protein function, promote inflammation, and impair cellular signaling—hallmarks of neurodegenerative diseases. MG also crosslinks DNA polymerase and substrate DNA, inhibiting DNA replication and repair. This genotoxicity exacerbates neuronal damage and accelerates disease progression in conditions such as Alzheimer’s and Parkinson’s disease. Elevated MG levels have been observed in aging brains and in models of metabolic dysfunction, linking it to both neurodegeneration and systemic disease. Therapeutic strategies aimed at reducing MG accumulation or enhancing its detoxification via the glyoxalase system are under investigation. As a biomarker and mediator of oxidative damage, MG represents a critical target in the study and treatment of neurodegenerative disorders. This antibody is also available conjugated to ATTO 390, ATTO 488, ATTO 594, APC, Biotin, FITC, HRP, PerCP and RPE. Supplied in 100 µg. For research use only; not for diagnostic or therapeutic procedures.

Product Name:Methylglyoxal Antibody [9E7]
Product SKU:STMA00186
Size:100 µg
Target:Methylglyoxal
Host Species:Mouse
Antibody Type:Monoclonal
Clone ID:9E7
Research Areas:Cancer, Oxidative Stress, Lipid peroxidation
Buffer:PBS pH7.4, 50% glycerol, 0.09% sodium azide
Storage & Shipping:Store at -20°C. Shipped on Blue Ice or 4°C. Conjugated variants should be stored according to the product label.
Format:Liquid
Applications:WB, ICC/IF, IHC, FACS, FCM, ELISA
Antibody Isotype:IgG2a
Purification:Protein G Purified
Concentration:1 mg/ml
Reactivity:Species Independent
Recommended Dilution:WB (1:1000); ICC/IF (1:50); FACS (1:50); FCM (1:50); ELISA (1:1000); IHC (1:50); optimal dilutions for assays should be determined by the user.
Specificity:Specific for Methylglyoxal modified proteins. Does not detect free Methylglyoxal. Does not cross-react with Acrolein, Hexanoyl Lysine, Malondialdeyhde, 4-Hydroxy-2-hexenal, 4-Hydroxy nonenal, or Crotonaldehyde modified proteins.
Guarantee:12 months from date of dispatch
Immunogen:Synthetic Methylglyoxal modified Keyhole Limpet Hemocyanin (KLH).
Alternative Names:Methylglyoxal, 2-Oxopropanal, 2 oxo propanal, MG, Pyruvaldehyde, Methylglyoxal (MG), MG-modified protein
References:1. Negre-Salvayre et al. (2008) Br J Pharmacol. 153(1):6-20. 2. Murata-Kamiya, N., Kamiya, H. (2001) Nucleic Acids Res. 29(16): 3433-3438.
Note:For research use only.

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