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Purified Anti-Mouse CD117 Antibody [2B8] (AGEL0336)

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SKU:
AGEL0336
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Host Species:
Rat
Isotype:
IgG2b
Clone:
2B8
Conjugation:
Unconjugated
Applications:
FC
IHC
IP
$131 - $143

Description

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Purified Anti-Mouse CD117 Antibody [2B8]

The Mouse CD117 Monoclonal Antibody (2B8, AGEL0336) is a powerful tool for researchers investigating CD117, a key cell surface marker associated with stem cell and progenitor cell populations. This monoclonal antibody, derived from mouse hybridoma cells, demonstrates high specificity and sensitivity in recognizing CD117 in mouse samples. Validated for use in various applications including flow cytometry and immunohistochemistry, it enables accurate detection and analysis of CD117-expressing cells in research related to hematopoiesis, hematological malignancies, and reproductive biology.CD117, also known as c-Kit, is a receptor tyrosine kinase involved in multiple cellular processes such as proliferation, differentiation, and survival.

Its expression on diverse cell types, including hematopoietic stem cells and mast cells, underscores its importance in normal development and disease pathogenesis. By targeting CD117, researchers can gain insights into the roles of stem cells in tissue regeneration, cancer progression, and other physiological processes. This monoclonal antibody serves as a valuable tool for elucidating the functions and mechanisms associated with CD117, paving the way for advancements in regenerative medicine, oncology, and developmental biology.

Product Title:Purified Anti-Mouse CD117 Antibody [2B8]
SKU:AGEL0336
Size:25µg, 100µg
Clone No:2B8
Synonyms:Mast/stem cell growth factor receptor Kit;Kit;SCFR;Proto-oncogene c-Kit;Tyrosine-protein kinase Kit;CD117;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2b, κ
Isotype Control:Purified Rat IgG2b, κ Isotype Control[LTF-2]
Form:Liquid
Conjugation:Unconjugated
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 2.0 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Swissprot:P05532
Gene ID:16590
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD117 is a 145 kD immunoglobulin superfamily member also known as c-Kit and stem cell factor receptor (SCFR). It is a transmembrane tyrosine-kinase receptor that binds the c-Kit ligand (also known as steel factor, stem cell factor, and mast cell growth factor). CD117 is expressed on hematopoietic stem cells (including multipotent hematopoietic stem cells, progenitors committed to myeloid and/or erythroid lineages, and T and B cell precursors), mast cells, and acute myeloid leukemia (AML) cells. CD117 interaction with its ligand is critical for the development of hematopoietic stem cells.

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