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PE Anti-Mouse MHC II (I-A/I-E) Antibody [M5/114] (AGEL0021)

Datasheet MSDS
SKU AGEL0021
Product Type Antibody
Antibody Type Monoclonal Antibody
Reactivity Mouse
Host Species Rat
Isotype IgG2b
Clone M5/114
Conjugation PE
Applications FC
$46 - $119

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Description

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PE Anti-Mouse MHC II (I-A/I-E) Antibody [M5/114]

The PE-Conjugated Mouse I-A/I-E Monoclonal Antibody (M5/114) is meticulously designed for research involving I-A/I-E, essential molecules within the Major Histocompatibility Complex (MHC) class II system that play pivotal roles in antigen presentation and immune response activation. This monoclonal antibody, generated in mice, is highly specific for mouse I-A/I-E and is validated for use in flow cytometry applications. Its conjugation with phycoerythrin (PE) ensures bright and stable red fluorescence, facilitating precise and reliable detection.I-A/I-E molecules are critical for the adaptive immune response, playing a key role in presenting antigens to CD4+ T cells. Their significant function in immune regulation makes them valuable targets for research into autoimmune disorders, chronic inflammatory conditions, and infectious diseases.

The PE-Conjugated Mouse I-A/I-E Monoclonal Antibody (M5/114) is an indispensable tool for researchers aiming to explore the mechanisms of antigen presentation and develop therapies that modulate immune function.By enabling accurate and sensitive detection of I-A/I-E molecules, this antibody supports comprehensive studies of immune response pathways, contributing to the development of novel therapeutic strategies for autoimmune diseases and other immune-related conditions. Understanding the activity of I-A/I-E is crucial for the creation of innovative immunotherapies that harness or modulate antigen presentation in various disease contexts.

Product Title:PE Anti-Mouse MHC II (I-A/I-E) Antibody [M5/114]
SKU:AGEL0021
Size:50 Tests, 100 Tests, 200 Tests
Clone No:M5/114
Synonyms:H2-Ab1/Eb1;Major histocompatibility protein class II beta chain;MHC class II H2-IA-beta-psi;I-E beta MHC class II;MHC class II;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2b, κ
Isotype Control:PE Rat IgG2b, κ Isotype Control[LTF-2]
Form:Liquid
Conjugation:PE
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:P14483 O78196
Gene ID:14961,14969
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:These class II molecules are expressed on antigen presenting cells (including B cells) and a subset of T cells from H-2b,d,q,r bearing mice and are involved in antigen presentation to T cells expressing CD3/TCR and CD4 proteins.
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