The NFE2 Polyclonal Antibody (PACO10828) is a valuable tool for researchers studying NFE2, a transcription factor involved in the regulation of oxidative stress response and hematopoiesis. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human NFE2 samples, making it ideal for Western blot applications. By binding to the NFE2 protein, this antibody enables the accurate detection and analysis of NFE2 expression in various cell types.NFE2, also known as nuclear factor erythroid 2, plays a crucial role in maintaining cellular redox balance and protecting cells from oxidative damage. Its involvement in the regulation of antioxidant enzymes and stress response pathways highlights its significance in diseases related to oxidative stress, such as cancer, neurodegenerative disorders, and cardiovascular conditions.
By studying the function of NFE2, researchers can gain valuable insights into potential therapeutic targets and strategies for managing oxidative stress-related diseases.Overall, the NFE2 Polyclonal Antibody (PACO10828) offers a reliable tool for investigating the role of NFE2 in cellular physiology and disease pathogenesis, making it a valuable asset for studies in molecular biology, biochemistry, and biomedical research.
NF-E2: a transcription factor of the bZIP family, CNC subfamily. May play a role in all aspects of hemoglobin production: globin synthesis, heme synthesis, and the procurement of iron. Required for activity at the locus control region (LCR) upstream of the globin gene complexes. Requires p18 NF-E2 for binding to the NF-E2 motif. Expressed in hematopoietic cells and also in colon and testis.Protein type: DNA-binding; Transcription factor; CytoskeletalChromosomal Location of Human Ortholog: 12q13Cellular Component: actin cytoskeleton; cytoplasm; nucleoplasm; nucleusMolecular Function: protein binding; protein N-terminus binding; sequence-specific DNA binding; transcription coactivator activity; WW domain bindingBiological Process: blood circulation; blood coagulation; hemostasis; multicellular organismal development; nucleosome disassembly; positive regulation of transcription, DNA-dependent; regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent
