Description
NR2F6 Transcription Factor Activity Assay
The NR2F6 Transcription Factor Activity Assay kit is a versatile tool for measuring the activity of the NR2F6 transcription factor in cell lysates. This assay kit offers high sensitivity and specificity, providing precise and reliable results for research applications.NR2F6, also known as COUP-TFIII, is a key transcription factor that regulates various biological processes, including cell differentiation, metabolism, and immune response. Dysregulation of NR2F6 has been implicated in several diseases, including cancer and autoimmune disorders, making it a valuable target for drug discovery and therapeutic interventions.
With this NR2F6 Transcription Factor Activity Assay kit, researchers can accurately assess the activity of NR2F6 in their samples, allowing for in-depth studies of its role in disease development and progression. Don't miss out on this valuable tool for advancing your research in the field of transcription factor biology.
| Product Name: | NR2F6 Transcription Factor Activity Assay |
| Product Code: | TFAB00143 |
| Target: | NR2F6 |
| Reactivity: | Human, Mouse |
| Sample Types: | Nuclear or cell lysates |
The Assay Genie NR2F6 transcription factor activity assay allows for the detection and qualitative analysis of endogenous levels of activated transcription factors in a variety of nuclear and cell lysates
Assay Genie ELISA kits are designed to significantly reduce experiment time and ensure sensitivity and flexibility for high-throughput screening.
| Assay Time: | 4.5 hours |
| Detection Method: | Colorimetric 450 nm |
| Size: | 12 x 8-Well Microstrips |
| Storage: | 4°C for 6 months |
| UniProt Protein Function: | EAR-2: Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type- specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC). Belongs to the nuclear hormone receptor family. NR2 subfamily. |
| UniProt Protein Details: | Protein type:Nuclear receptor; DNA-binding Chromosomal Location of Human Ortholog: 19p13.1 Cellular Component: nucleoplasm; nucleus Molecular Function:DNA binding; ligand-dependent nuclear receptor activity; protein binding; sequence-specific DNA binding; thyroid hormone receptor activity; transcription factor activity Biological Process: negative regulation of transcription from RNA polymerase II promoter; signal transduction; transcription initiation from RNA polymerase II promoter |
| UniProt Code: | P10588 |
| NCBI GenInfo Identifier: | 23503053 |
| NCBI Gene ID: | 2063 |
| NCBI Accession: | P10588.2 |
| UniProt Secondary Accession: | P10588,Q5XGA0, Q6P586, Q9BUE8, B2RC68, |
| UniProt Related Accession: | P10588 |
| Molecular Weight: | 42,979 Da |
| NCBI Full Name: | Nuclear receptor subfamily 2 group F member 6 |
| NCBI Synonym Full Names: | nuclear receptor subfamily 2 group F member 6 |
| NCBI Official Symbol: | NR2F6 |
| NCBI Official Synonym Symbols: | EAR2; EAR-2; ERBAL2 |
| NCBI Protein Information: | nuclear receptor subfamily 2 group F member 6 |
| UniProt Protein Name: | Nuclear receptor subfamily 2 group F member 6 |
| UniProt Synonym Protein Names: | V-erbA-related protein 2; EAR-2 |
| Protein Family: | Nuclear receptor subfamily |
| UniProt Gene Name: | NR2F6 |
| UniProt Entry Name: | NR2F6_HUMAN |
