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Anti-OGDHL Antibody (CAB15475)

SKU:
CAB15475
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Metabolism
  • Metabolism Antibodies 1 Anti-OGDHL Antibody CAB15475
  • Metabolism Antibodies 1 Anti-OGDHL Antibody CAB15475
  • Metabolism Antibodies 1 Anti-OGDHL Antibody CAB15475
€139 - €419
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Description

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Antibody Name:Anti-OGDHL Antibody
Antibody SKU:CAB15475
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-110 of human OGDHL (NP_060715.2).
Application:WB IHC
Recommended Dilution:WB 1:200 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:LO2, Mouse kidney, Mouse brain, Rat kidney
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-110 of human OGDHL (NP_060715.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MSQL RLLP SRLG VQAA RLLA AHDV PVFG WRSR SSGP PATF PSSK GGGG SSYM EEMY FAWL ENPQ SVHK SWDS FFRE ASEE AFSG SAQP RPPS VVHE SRSA VSSR TKTS KL
Gene ID:55753
Uniprot:Q9ULD0
Cellular Location:Mitochondrion matrix
Calculated MW:91kDa/108kDa/114kDa
Observed MW:120kDa
Synonyms:OGDHL
Background:The protein encoded by this gene is similar to oxoglutarate dehydrogenase (OGDH) of the OGDH complex, which degrades glucose and glutamate. This gene encodes several isoforms, including some that appear to localize to mitochondria. The encoded protein down-regulates the AKT signaling cascade and can suppress the growth of cervical cancer cells.
UniProt Protein Function:OGDHL: Belongs to the alpha-ketoglutarate dehydrogenase family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Mitochondrial; Oxidoreductase; EC 1.2.4.-; Amino Acid Metabolism - lysine degradation; Amino Acid Metabolism - tryptophan; Carbohydrate Metabolism - citrate (TCA) cycle

Chromosomal Location of Human Ortholog: 10q11.23

Cellular Component: mitochondrion; mitochondrial matrix; oxoglutarate dehydrogenase complex; cytosol

Molecular Function:protein binding; metal ion binding; thiamin pyrophosphate binding; oxoglutarate dehydrogenase (succinyl-transferring) activity

Biological Process: glycolysis; tricarboxylic acid cycle

NCBI Summary:The protein encoded by this gene is similar to oxoglutarate dehydrogenase (OGDH) of the OGDH complex, which degrades glucose and glutamate. This gene encodes several isoforms, including some that appear to localize to mitochondria. The encoded protein down-regulates the AKT signaling cascade and can suppress the growth of cervical cancer cells. [provided by RefSeq, Dec 2016]
UniProt Code:Q9ULD0
NCBI GenInfo Identifier:160419019
NCBI Gene ID:55753
NCBI Accession:Q9ULD0.3
UniProt Related Accession:Q9ULD0
Molecular Weight:91kDa; 108kDa; 114kDa
NCBI Full Name:2-oxoglutarate dehydrogenase-like, mitochondrial
NCBI Synonym Full Names:oxoglutarate dehydrogenase like
NCBI Official Symbol:OGDHL  
NCBI Protein Information:2-oxoglutarate dehydrogenase-like, mitochondrial
UniProt Protein Name:2-oxoglutarate dehydrogenase-like, mitochondrial
UniProt Synonym Protein Names:2-oxoglutarate dehydrogenase complex component E1-like; OGDC-E1-like; Alpha-ketoglutarate dehydrogenase-like
Protein Family:2-oxoglutarate dehydrogenase
UniProt Gene Name:OGDHL  
UniProt Entry Name:OGDHL_HUMAN
Anti-OGDHL Antibody (CAB15475)Western blot analysis of extracts of various cell lines, using OGDHL antibody (CAB15475) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s.
Anti-OGDHL Antibody (CAB15475)Immunohistochemistry of paraffin-embedded human esophageal using OGDHL Rabbit pAb (CAB15475) at dilution of 1:200 (40x lens).
Anti-OGDHL Antibody (CAB15475)Immunohistochemistry of paraffin-embedded mouse heart using OGDHL Rabbit pAb (CAB15475) at dilution of 1:200 (40x lens).

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