Description

PE/Cyanine7 Anti-Mouse CD8a Antibody [53-6.7]

The PE-Cyanine7 Anti-Mouse CD8a Antibody (Clone: 53-6.7) offered by AssayGenie is a high-quality antibody specifically designed for researchers working with mouse models to study CD8a, a crucial cell surface marker involved in cytotoxic T cell function. This antibody, raised in mice, exhibits high reactivity and specificity towards mouse CD8a samples and is validated for use in flow cytometry applications.CD8a, also known as CD8 alpha chain, is essential for the activation of cytotoxic T cells and plays a key role in immune responses against infections and cancer. Monitoring CD8a expression levels is vital for understanding the immune response and evaluating T cell populations in different experimental settings.

This antibody enables precise detection and analysis of CD8a-expressing cells, facilitating detailed investigations into immune cell subsets and responses in cancer immunology, infectious diseases, and autoimmune conditions.AssayGenie's PE-Cyanine7 Anti-Mouse CD8a Antibody (Clone: 53-6.7) provides researchers with a powerful tool to advance their studies in immunology, tumor immunotherapy, and vaccine development using mouse models. By targeting CD8a, researchers can gain valuable insights into T cell-mediated immunity and potentially uncover novel therapeutic strategies for enhancing immune responses against various diseases.

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Product Title:	PE/Cyanine7 Anti-Mouse CD8a Antibody [53-6.7]
SKU:	AGEL2203
Size:	50 Tests, 100 Tests, 200 Tests
Clone No:	53-6.7
Synonyms:	T-cell surface glycoprotein CD8 alpha chain;CD8A;T-lymphocyte differentiation antigen T8/Leu-2;MAL;
Host Species:	Rat
Reactivity:	Mouse
Application:	FCM

Isotype:	Rat IgG2a, κ
Isotype Control:	PE/Cyanine7 Rat IgG2a, κ Isotype Control[2A3]
Form:	Liquid
Conjugation:	PE/Cyanine 7
Recommended Use:	Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:

Swissprot:	P01731
Gene ID:	12525
Storage Buffer:	Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:	Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:	CD8, also known as Lyt-2, Ly-2, or T8, consists of disulfide-linked α and β chains that form the α(CD8a)/β(CD8b) heterodimer and α/α homodimer. CD8a is a 34 kD protein that belongs to the immunoglobulin family. The CD8 α/β heterodimer is expressed on the surface of most thymocytes and a subset of mature TCR α/β T cells. CD8 expression on mature T cells is non-overlapping with CD4. The CD8 α/α homodimer is expressed on a subset of γ/δ TCR-bearing T cells, NK cells, intestinal intraepithelial lymphocytes, and lymphoid dendritic cells. CD8 is an antigen co-receptor on T cells that interacts with MHC class I on antigen-presenting cells or epithelial cells. CD8 promotes T cell activation through its association with the TCR complex and protein tyrosine kinase lck.

PE/Cyanine7 Anti-Mouse CD8a Antibody [53-6.7] (AGEL2203)

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Description