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Anti-PLSCR1 Antibody (CAB6691)

SKU:
CAB6691
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology
  • Immunology Antibodies 2 Anti-PLSCR1 Antibody CAB6691
  • Immunology Antibodies 2 Anti-PLSCR1 Antibody CAB6691
€139 - €419
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Description

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Antibody Name:Anti-PLSCR1 Antibody
Antibody SKU:CAB6691
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-318 of human PLSCR1 (NP_066928.1).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human
Positive Samples:THP-1, HT-29
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-318 of human PLSCR1 (NP_066928.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MDKQ NSQM NASH PETN LPVG YPPQ YPPT AFQG PPGY SGYP GPQV SYPP PPAG HSGP GPAG FPVP NQPV YNQP VYNQ PVGA AGVP WMPA PQPP LNCP PGLE YLSQ IDQI LIHQ QIEL LEVL TGFE TNNK YEIK NSFG QRVY FAAE DTDC CTRN CCGP SRPF TLRI IDNM GQEV ITLE RPLR CSSC CCPC CLQE IEIQ APPG VPIG YVIQ TWHP CLPK FTIQ NEKR EDVL KISG PCVV CSCC GDVD FEIK SLDE QCVV GKIS KHWT GILR EAFT DADN FGIQ FPLD LDVK MKAV MIGA CFLI DFMF FEST GSQE QKSG VW
Gene ID:5359
Uniprot:O15162
Cellular Location:Cell membrane, Cytoplasmic side, Lipid-anchor, Membrane, Nucleus, Single-pass type II membrane protein
Calculated MW:26kDa/35kDa
Observed MW:35kDa
Synonyms:PLSCR1, MMTRA1B
Background:
UniProt Protein Function:PLSCR1: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system. Belongs to the phospholipid scramblase family.
UniProt Protein Details:

Protein type:Calcium-binding; Membrane protein, integral

Chromosomal Location of Human Ortholog: 3q23

Cellular Component: extracellular matrix; Golgi apparatus; membrane; integral to plasma membrane; nucleolus; plasma membrane; cytosol; nucleus; lipid raft

Molecular Function:phospholipid scramblase activity; protein binding; enzyme binding; DNA binding; calcium ion binding; CD4 receptor binding; SH3 domain binding; epidermal growth factor receptor binding

Biological Process: platelet activation; negative regulation of viral genome replication; apoptosis; positive regulation of innate immune response; acute-phase response; positive regulation of transcription from RNA polymerase II promoter; phospholipid scrambling; defense response to virus; regulation of mast cell activation; phosphatidylserine biosynthetic process

UniProt Code:O15162
NCBI GenInfo Identifier:14548191
NCBI Gene ID:5359
NCBI Accession:O15162.1
UniProt Secondary Accession:O15162,B2R8H8, B4DTE8,
UniProt Related Accession:O15162
Molecular Weight:318
NCBI Full Name:Phospholipid scramblase 1
NCBI Synonym Full Names:phospholipid scramblase 1
NCBI Official Symbol:PLSCR1  
NCBI Official Synonym Symbols:MMTRA1B  
NCBI Protein Information:phospholipid scramblase 1; PL scramblase 1; erythrocyte phospholipid scramblase; ca(2+)-dependent phospholipid scramblase 1
UniProt Protein Name:Phospholipid scramblase 1
UniProt Synonym Protein Names:Ca(2+)-dependent phospholipid scramblase 1; Erythrocyte phospholipid scramblase; MmTRA1b
Protein Family:Phospholipid scramblase
UniProt Gene Name:PLSCR1  
UniProt Entry Name:PLS1_HUMAN
Anti-PLSCR1 Antibody (CAB6691)Western blot analysis of extracts of various cell lines, using PLSCR1 antibody (CAB6691) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s.
Anti-PLSCR1 Antibody (CAB6691)Immunofluorescence analysis of HeLa cells using PLSCR1 antibody (CAB6691). Blue: DAPI for nuclear staining.

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