Anti-Profilin1 Antibody (CAB9188)

SKU:
CAB9188
€129 - €349

Description

Technical Manual

Anti-Profilin1 Antibody

Product Name:Anti-Profilin1 Antibody
Product SKU:CAB9188
Size:20uL, 50 uL
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Background:

This gene encodes a member of the profilin family of small actin-binding proteins. The encoded protein plays an important role in actin dynamics by regulating actin polymerization in response to extracellular signals. Deletion of this gene is associated with Miller-Dieker syndrome, and the encoded protein may also play a role in Huntington disease. Multiple pseudogenes of this gene are located on chromosome 1. [provided by RefSeq, Jul 2012]

Immunogen:A synthesized peptide derived from human Profilin1
Sequence:

Email for sequence

Gene ID:5216
Swiss Prot:P07737
Synonyms:ALS18
Calculated MW:15kDa
Observed MW:15KDa
Reactivity:Human, Mouse, Rat
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Application Key:Western blotting 
Positive Samples:HeLa, A-549, NIH/3T3, C6, U-251MG, Mouse brain, Mouse thymus, Rat kidney
Cellular Location:

Product Images

Anti-Profilin1 Antibody (CAB9188)

Western blot - Profilin1 Rabbit mAb (CAB9188)

Uniprot Information

UniProt Protein Function:profilin 1: a ubiquitous actin monomer-binding protein belonging to the profilin family. At high concentrations, profilin 1 prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Deletion of this gene is associated with Miller-Dieker syndrome.
UniProt Protein Details:

Protein type:Cytoskeletal; Motility/polarity/chemotaxis; Actin-binding

Chromosomal Location of Human Ortholog: 17p13.3

Cellular Component: cell cortex; cytoplasm; cytosol; focal adhesion; membrane; nucleus

Molecular Function:actin binding; actin monomer binding; adenyl-nucleotide exchange factor activity; phosphatidylinositol-4,5-bisphosphate binding; protein binding

Biological Process: negative regulation of actin filament bundle formation; negative regulation of actin filament polymerization; negative regulation of stress fiber formation; positive regulation of actin filament bundle formation; positive regulation of actin filament polymerization; positive regulation of ATPase activity; protein stabilization; Wnt receptor signaling pathway, planar cell polarity pathway

Disease: Amyotrophic Lateral Sclerosis 18

NCBI Summary:This gene encodes a member of the profilin family of small actin-binding proteins. The encoded protein plays an important role in actin dynamics by regulating actin polymerization in response to extracellular signals. Deletion of this gene is associated with Miller-Dieker syndrome, and the encoded protein may also play a role in Huntington disease. Multiple pseudogenes of this gene are located on chromosome 1. [provided by RefSeq, Jul 2012]
UniProt Code:P07737
NCBI GenInfo Identifier:130979
NCBI Gene ID:5216
NCBI Accession:P07737.2
UniProt Secondary Accession:P07737,Q53Y44,
UniProt Related Accession:P07737
Molecular Weight:15,054 Da
NCBI Full Name:Profilin-1
NCBI Synonym Full Names:profilin 1
NCBI Official Symbol:PFN1 
NCBI Official Synonym Symbols:ALS18 
NCBI Protein Information:profilin-1
UniProt Protein Name:Profilin-1
UniProt Synonym Protein Names:Epididymis tissue protein Li 184a; Profilin I
UniProt Gene Name:PFN1 
UniProt Entry Name:PROF1_HUMAN
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Additional Information

Product type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Monoclonal Antibody
Research Area:
Cell Biology
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