RBFOX3 Antibody (PACO18292)
- SKU:
- PACO18292
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| Antibody Name: | RBFOX3 Antibody (PACO18292) |
| Antibody SKU: | PACO18292 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:1000-1:2000, IHC:1:15-1:50 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Synthetic peptide of human RBFOX3 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO18292(RBFOX3 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | Immunoprecipitation and mass spectrometry of the two major NeuN species at 4550 kDa identified both as the RNA binding protein Rbfox3 (a member of the Fox family of alternative splicing factors), confirming and extending the identification of the 45 kDa band as Rbfox3. Mapping of the anti-NeuN reactive epitopes in both R3hdm2 and Rbfox3 reveals a common proline- and glutamine-rich domain that lies at the N-terminus of the Rbfox3 protein. Nuclear Rbfox3 isoforms can also enhance the inclusion of cryptic exons in the Rbfox2 mRNA, resulting in nonsense-mediated decay of the message, thereby contributing to the negative regulation of Rbfox2 by Rbfox3 through a novel mechanism. |
| Synonyms: | RNA binding protein, fox-1 homolog (C. elegans) 3 |
| UniProt Protein Function: | NeuN: RNA-binding protein that regulates alternative splicing events. |
| UniProt Protein Details: | Protein type:RNA splicing; RNA processing; DNA-binding Chromosomal Location of Human Ortholog: 17q25.3 Cellular Component: cytoplasm; perikaryon; nucleus Molecular Function:DNA binding; RNA binding; nucleotide binding Biological Process: RNA splicing; mRNA processing; regulation of alternative nuclear mRNA splicing, via spliceosome |
| UniProt Code: | A6NFN3 |
| NCBI GenInfo Identifier: | 322510139 |
| NCBI Gene ID: | |
| NCBI Accession: | A6NFN3.4 |
| Molecular Weight: | 46-55kDa |
| NCBI Full Name: | RNA binding protein fox-1 homolog 3 |
| UniProt Protein Name: | RNA binding protein fox-1 homolog 3 |
| UniProt Synonym Protein Names: | Fox-1 homolog C |
| UniProt Gene Name: | RBFOX3 |
| UniProt Entry Name: | RFOX3_HUMAN |
| Antibodies |
| Anti-NeuN Antibody (CAB0951)[KO Validated] |
| Anti-RBFOX3 Antibody (CAB15959) |
| Anti-RBFOX3 Antibody (CAB17261) |
| Anti-NeuN Antibody (CAB19086) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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