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[KO Validated] SIRT1 Rabbit Polyclonal Antibody (CAB17307)

SKU:
CAB17307
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Death
  • KO Validated Antibodies 1 Anti-SIRT1 Antibody CAB17307KO Validated
  • KO Validated Antibodies 1 Anti-SIRT1 Antibody CAB17307KO Validated
  • KO Validated Antibodies 1 Anti-SIRT1 Antibody CAB17307KO Validated
  • KO Validated Antibodies 1 Anti-SIRT1 Antibody CAB17307KO Validated
  • KO Validated Antibodies 1 Anti-SIRT1 Antibody CAB17307KO Validated
€139 - €419
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Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:[KO Validated] SIRT1 Rabbit Polyclonal Antibody
SKU:CAB17307
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 448-747 of human SIRT1 (NP_036370.2).
Sequence:VALI PSSI PHEV PQIL INRE PLPH LHFD VELL GDCD VIIN ELCH RLGG EYAK LCCN PVKL SEIT EKPP RTQK ELAY LSEL PPTP LHVS EDSS SPER TSPP DSSV IVTL LDQA AKSN DDLD VSES KGCM EEKP QEVQ TSRN VESI AEQM ENPD LKNV GSST GEKN ERTS VAGT VRKC WPNR VAKE QISR RLDG NQYL FLPP NRYI FHGA EVYS DSED DVLS SSSC GSNS DSGT CQSP SLEE PMED ESEI EEFY NGLE DEPD VPER AGGA GFGT DGDD QEAI NEAI SVKQ EVTD MNYP SNKS
Tested Applications:WB IF/ICC ELISA
Recommended Dilution:WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200
Synonyms:SIR2; SIR2L1; SIR2alpha; SIRT1
Positive Sample:293T,HeLa,Jurkat,NIH/3T3,C6
Conjugate:Unconjugated
Cellular Localization:Cytoplasm, Mitochondrion, Nucleus, Nucleus, PML body.
Calculated MW:82kDa
Observed MW:120kDa

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants.

Purification Method:Affinity purification
Gene ID:23411
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates using SIRT1 Rabbit pAb (CAB17307) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.

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