The Recombinant ALKBH2 Monoclonal Antibody is a recombinant rabbit monoclonal antibody (clone C130851) against ALKBH2. The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 and ALKBH3 (MIM 610603) are E. coli AlkB homologs that catalyze the removal of 1-methyladenine and 3-methylcytosine (Duncan et al., 2002 [PubMed 12486230]). Produced by recombinant technology in Rabbit hosts and purified by Protein A affinity chromatography, this Rabbit IgG antibody is reactive against Human, Mouse and Rat samples.
This antibody is suitable for WB and FC applications. It has been validated by WB analysis of HeLa. The target is localized to the nucleus, nucleus, nucleolus, nucleus, nucleoplasm, Relocates to the replication foci during S-phase.