The Recombinant Cadherin-6 Monoclonal Antibody is a recombinant rabbit monoclonal antibody (clone C331629) against Cadherin-6. Cadherin-6, also known as kidney cadherin (K-Cadherin, CDH6) is a type II classical cadherin. While it was reported to have a tumor suppressor function in cholangiocarcinoma, cadherin-6 expression was shown to be a marker of epithelial mesenchymal transition, and positively correlated with stage and metastasis of papillary thyroid carcinoma. In related studies, cadherin-6 was shown to interact with GABARAP and related proteins to restrain autophagy, thereby promoting metastatic behavior. Produced by recombinant technology in Rabbit hosts and purified by Protein A affinity chromatography, this Rabbit IgG antibody is reactive against Human samples.
This antibody is suitable for WB applications. It has been validated by WB analysis of HeLa,?293T, U-87 MG, HepG2. The target is localized to the cell membrane.
Peptide. This information is proprietary to PTMab.
Applications:
WB
Clonality:
Recombinant Monoclonal
Clone No:
C331629
Host:
Rabbit
Isotype:
Rabbit IgG
Target:
Cadherin-6
Conjugation:
Unconjugated
Observed MW:
130 kDa
Calculated MW:
88 kDa
Recommended Dilution:
WB 1:1000
UniProt:
P55285
Purification:
Protein A
Concentration:
1 mg/mL
Buffer:
PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Storage:
Store at -20°C valid for 12 months. Avoid freeze / thaw cycles.
Western Blot with Cadherin-6 Monoclonal Antibody at dilution of 1:1000. Lane 1: HeLa, Lane 2: 293T, Lane 3: U- 87 MG, Lane 4: HepG2 Observed-MW:130 kDa Calculated-MW:88 kDa
