The Recombinant CD146 Monoclonal Antibody is a recombinant rabbit monoclonal antibody (clone C131386) against CD146. CD146 plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Produced by recombinant technology in Rabbit hosts and purified by Protein A affinity chromatography, this Rabbit IgG antibody is reactive against Human, Mouse and Rat samples.
This antibody is suitable for WB and IP applications. It has been validated by WB analysis of HeLa, PC-12, Mouse lung, Rat lung and IP analysis of HeLa cells extracts. The target is localized to the membrane.