The Recombinant CD79a Monoclonal Antibody is a recombinant rabbit monoclonal antibody (clone C311109) against CD79a. Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Produced by recombinant technology in Rabbit hosts and purified by Protein A affinity chromatography, this Rabbit IgG antibody is reactive against Human samples.
This antibody is suitable for WB, IHC-P and ICC/IF applications. It has been validated by WB analysis of Jurkat, IHC analysis of Human tonsil and IF analysis of HL-60. The target is localized to the membrane.