The Recombinant Cdc23 Monoclonal Antibody is a recombinant rabbit monoclonal antibody (clone C171432) against Cdc23. CDC23, also known as APC8, is a component of the tetratricopeptide repeat (TPR) APC/C sub-complex that also includes APC3 (CDC27) and APC6 (CDC16). APC8 protein associates with APC3 and APC6 to facilitate the recruitment of the APC/C coactivation subunits CDC20 and Cdh1/FZR1. APC8 protein is overexpressed in papillary thyroid cancer and acts as an important regulator of cell cycle progression and cell growth. Produced by recombinant technology in Rabbit hosts and purified by Protein A affinity chromatography, this Rabbit IgG antibody is reactive against Human, Mouse and Rat samples.
This antibody is suitable for WB and ICC/IF applications. It has been validated by WB analysis of Jurkat, HeLa, Mouse kidney, Rat kidney and IF analysis of HeLa. The target is localized to the cytosol, nucleus.