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Recombinant CHD4 Monoclonal Antibody (AGEL6859)

Datasheet MSDS
SKU AGEL6859
Product Type Antibody
Reactivity Human, Mouse
Applications WB, ICC/IF, FC, IP
Host Species Rabbit
Clonality Monoclonal
Clone C271554
Conjugate Unconjugated
$606 - $843

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Description

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Recombinant CHD4 Monoclonal Antibody

The Recombinant CHD4 Monoclonal Antibody is a recombinant rabbit monoclonal antibody (clone C271554) against CHD4. Chromodomain helicase DNA-binding protein 4 (CHD4) is an ATP dependent chromatin remodeler and a major subunit of the repressive NuRD complex. This complex plays key roles in transcriptional regulation and reorganization and maintenance of chromatin structure, as it targets pericentromeric heterochromatin and has recently been implicated in DNA damage repair, being rapidly recruited to DNA double strand breaks. CHD4 is a novel BRIT1 binding partner that regulates the HR repair process, which is a critical pathway of repairing DNA double strand breaks and plays an essential role in maintaining genomic integrity. Produced by recombinant technology in Rabbit hosts and purified by Protein A affinity chromatography, this Rabbit IgG antibody is reactive against Human and Mouse samples.

This antibody is suitable for WB, ICC/IF, FC and IP applications. It has been validated by IF analysis of HeLa. The target is localized to the nucleus.

Product Name:Recombinant CHD4 Monoclonal Antibody
SKU:AGEL6859
Size:50 µL, 100 µL
Antibody Type:Recombinant Monoclonal Antibody
Synonyms:CHD, CHD-4, CHD4, Mi-2b, Mi2-BETA, SIHIWES
Reactivity:Human, Mouse
Immunogen:A synthetic peptide of human CHD4
Applications:WBICC/IFFCIP
Clonality:Recombinant Monoclonal
Clone No:C271554
Host:Rabbit
Isotype:Rabbit IgG
Target:CHD4
Conjugation:Unconjugated
Observed MW:260 kDa
Calculated MW:218 kDa
Recommended Dilution:WB 1:1000; ICC/IF 1:200-500; IP 1:20-50; FCM 1:200-500
UniProt:Q14839
Purification:Protein A
Concentration:1 mg/mL
Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Storage:Store at -20°C valid for 12 months. Avoid freeze / thaw cycles.
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