The Recombinant DNMT3B Monoclonal Antibody is a recombinant rabbit monoclonal antibody (clone C331691) against DNMT3B. The DNMT3 family consists of two active methyltransferases, DNMT3A and DNMT3B, along with a DNMT3-like protein known as DNMT3L.DNMT3B plays a crucial role in regulating specific DNA methylation patterns, particularly during de novo methylation. It may function as atranscriptional corepressor by associating with CBX4 independently of DNA methylation. Mutations in the DNMT3B gene lead toImmunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. Produced by recombinant technology in Rabbit hosts and purified by Protein A affinity chromatography, this Rabbit IgG antibody is reactive against Human samples.
This antibody is suitable for WB and ChIP applications. It has been validated by WB analysis of HEK-293(Low expression), K562 and ChIP analysis of NCCIT. The target is localized to the nucleus.
Product Name:
Recombinant DNMT3B Monoclonal Antibody
SKU:
AGEL6996
Size:
50 µL, 100 µL
Antibody Type:
Recombinant Monoclonal Antibody
Synonyms:
DNA MTase HsaIIIB|DNA cytosine-5 methyltransferase 3 beta|DNA methyltransferase HsaIIIB, DNMT3B, ICF, ICF1, M. HsaIIIB
Reactivity:
Human
Immunogen:
Peptide. This information is proprietary to PTMab.
Applications:
WBChIP
Clonality:
Recombinant Monoclonal
Clone No:
C331691
Host:
Rabbit
Isotype:
Rabbit IgG
Target:
DNMT3B
Conjugation:
Unconjugated
Observed MW:
96 kDa
Calculated MW:
96 kDa
Recommended Dilution:
WB 1:1000-2000; ChIP 6 µg/2×10 6 cells
UniProt:
Q9UBC3
Purification:
Protein A
Concentration:
1 mg/mL
Buffer:
PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Storage:
Store at -20°C valid for 12 months. Avoid freeze / thaw cycles.
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