The Recombinant Drosha Monoclonal Antibody is a recombinant rabbit monoclonal antibody (clone C110785) against Drosha. This gene encodes a ribonuclease (RNase) III double-stranded RNA-specific ribonuclease and subunit of the microprocessor protein complex, which catalyzes the initial processing step of microRNA (miRNA) synthesis. The encoded protein cleaves the stem loop structure from the primary microRNA (pri-miRNA) in the nucleus, yielding the precursor miRNA (pre-miRNA), which is then exported to the cytoplasm for further processing. In a human cell line lacking a functional copy of this gene, canonical miRNA synthesis is reduced. Produced by recombinant technology in Rabbit hosts and purified by Protein A affinity chromatography, this Rabbit IgG antibody is reactive against Human, Mouse and Rat samples.
This antibody is suitable for WB, IHC, IF, IP and ELISA applications. It has been validated by WB analysis of Hela and IHC analysis of Human lung adenocarcinoma2. The target is localized to the nucleus, nucleus, nucleolus, A fraction is translocated to the nucleolus during the S phase of the cell cycle. Localized in GW bodies (GWBs), also known as p-bodies.
Product Name:
Recombinant Drosha Monoclonal Antibody
SKU:
AGEL6092
Size:
50 µL, 100 µL
Antibody Type:
Recombinant Monoclonal Antibody
Synonyms:
DROSHA, Drosha double stranded RNA specific endoribonuclease, Drosha ribonuclease type III, ETOHI, ETOHI2, HSA242976, Nuclear RNase III Drosha, p241, Protein Drosha, Putative protein p241 which interacts with transcription factor Sp1, Putative ribonuclease III, RANSE3L, Ribonuclease 3, Ribonuclease III, Ribonuclease III nuclear, Ribonuclease type III nuclear, RibonucleaseIII, RN 3, RN3, RNase 3, RNase III, RNase3, RNASE3L, RNaseIII, RNASEN, RNC
Reactivity:
Human, Mouse, Rat
Immunogen:
Recombinant Human Drosha protein
Applications:
WBIHCIFIPELISA
Clonality:
Recombinant Monoclonal
Clone No:
C110785
Host:
Rabbit
Isotype:
Rabbit IgG
Target:
Drosha
Conjugation:
Unconjugated
Observed MW:
159 kDa
Calculated MW:
159 kDa
Recommended Dilution:
IHC 1:200-1000; WB 1:2000-10000; IF 1:200-1000; ELISA 1:5000-20000; IP 1:50-200
UniProt:
Q9NRR4
Purification:
Protein A
Concentration:
0.2 mg/mL
Buffer:
PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Storage:
Store at -20°C valid for 12 months. Avoid freeze / thaw cycles.
![Anti-Drosha [R01-9I2] Monoclonal Antibody (AGMB00197)](https://cdn11.bigcommerce.com/s-h68l9z2lnx/images/stencil/590x590/products/271486/693018/anti-drosha-r01-9i2-monoclonal-antibody-agmb00197__25869.1774507999.jpg?c=2 "Anti-Drosha [R01-9I2] Monoclonal Antibody (AGMB00197)")
