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Key Features

Recombinant GSK3 beta Monoclonal Antibody (AGEL8541)

Datasheet MSDS
SKU AGEL8541
Product Type Antibody
Reactivity Human, Rat, Hamster
Applications WB
Host Species Rabbit
Clonality Monoclonal
Clone C733236
Conjugate Unconjugated
$461 - $632

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Description

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Recombinant GSK3 beta Monoclonal Antibody

The Recombinant GSK3 beta Monoclonal Antibody is a recombinant rabbit monoclonal antibody (clone C733236) against GSK3 beta. The protein encoded by this gene is a serine-threonine kinase belonging to the glycogen synthase kinase subfamily. It is a negative regulator of glucose homeostasis and is involved in energy metabolism, inflammation, ER-stress, mitochondrial dysfunction, and apoptotic pathways. Defects in this gene have been associated with Parkinson disease and Alzheimer disease. Produced by recombinant technology in Rabbit hosts and purified by affinity chromatography, this Rabbit IgG antibody is reactive against Human, Rat and Hamster samples.

This antibody is suitable for WB applications. It has been validated by WB analysis of Jurkat, C6, CHO-K1, Hela and IHC analysis of Human Cholangiocarcinoma. The target is localized to the Cytoplasm. Nucleus. Cell membrane. The phosphorylated form shows localization to cytoplasm and cell membrane. The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosophorylated form to the cell membrane.

Product Name:Recombinant GSK3 beta Monoclonal Antibody
SKU:AGEL8541
Size:50 µL, 100 µL
Antibody Type:Recombinant Monoclonal Antibody
Synonyms:Glycogen Synthase Kinase 3 Beta, Glycogen synthase kinase-3 beta, GSK 3 beta, GSK-3 beta, GSK3B, GSK3beta isoform, Serine/threonine-protein kinase GSK3B
Reactivity:Human, Rat, Hamster
Immunogen:A synthetic peptide of human GSK3 beta
Applications:WB
Clonality:Recombinant Monoclonal
Clone No:C733236
Host:Rabbit
Isotype:Rabbit IgG
Target:GSK3 beta
Conjugation:Unconjugated
Observed MW:47 kDa
Calculated MW:47 kDa
Recommended Dilution:WB 1:1000-2000
UniProt:P49841
Purification:Affinity purification
Concentration:0.3 mg/mL
Buffer:50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.05% stabilizer and 0.05% protective protein.
Storage:Store at -20°C valid for 12 months. Avoid freeze / thaw cycles.
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