Description
Recombinant Human CXCL10 Protein
| Background: | Human C-X-C Motif Chemokine Ligand 10 (CXCL10) is a non-ELR chemokine secreted by various cell types, such as monocytes, endothelial cells and fibroblasts, in response to IFN-?. CXCL10 functions via chemokine receptor CXCR3. CXCL10 has been attributed to several roles, such as chemoattraction for activated T-lymphocytes, inhibition of angiogenesis, and antitumor activity. |
| Name: | Recombinant Human CXCL10 Protein |
| Size: | 20 µg |
| Assay Genie SKU: | RPES1239 |
| Synonyms: | C-X-C Motif Chemokine 10; 10 kDa Interferon Gamma-Induced Protein; Gamma-IP10; IP0; Small-Inducible Cytokine B10; CXCL10; INP10; SCYB10 |
| Species: | Human |
| Expression host: | E.coli |
| Sequence: | Val22-Pro98 |
| Accession: | P02778 |
| Mol Mass: | 8.6 kDa |
| AP Mol Mass: | 13 kDa |
| Tag: | |
| Purity: | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin: | < 1.0 EU per µg as determined by the LAL method. |
| Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8? for 2-7 days. Aliquots of reconstituted samples are stable at < -20'C for 3 months. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation: | Lyophilized from a 0.2 um filtered solution of 20mM PB, 150mM NaCl, pH 7.0. |
| Reconstitution: | Please refer to the printed manual for detailed information. |
| UniProt Protein Function: | CXCL10: Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3. Belongs to the intercrine alpha (chemokine CxC) family. |
| UniProt Protein Details: | Protein type:Chemokine; Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 4q21 Cellular Component: extracellular space; extracellular region; external side of plasma membrane Molecular Function:heparin binding; protein binding; CXCR3 chemokine receptor binding; chemokine activity; cAMP-dependent protein kinase regulator activity; receptor binding Biological Process: muscle development; blood circulation; protein secretion; positive regulation of leukocyte chemotaxis; positive regulation of cAMP metabolic process; signal transduction; chemotaxis; regulation of cell proliferation; G-protein coupled receptor protein signaling pathway; negative regulation of angiogenesis; response to vitamin D; cell surface receptor linked signal transduction; cell-cell signaling; positive regulation of cell proliferation; response to gamma radiation; positive regulation of transcription from RNA polymerase II promoter; immune response; positive regulation of release of sequestered calcium ion into cytosol; response to cold; negative regulation of myoblast differentiation; inflammatory response; regulation of protein kinase activity; defense response to virus |
| NCBI Summary: | This antimicrobial gene encodes a chemokine of the CXC subfamily and ligand for the receptor CXCR3. Binding of this protein to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. [provided by RefSeq, Sep 2014] |
| UniProt Code: | P02778 |
| NCBI GenInfo Identifier: | 21542456 |
| NCBI Gene ID: | 3627 |
| NCBI Accession: | P02778.2 |
| UniProt Secondary Accession: | P02778,Q96QJ5, |
| UniProt Related Accession: | P02778 |
| Molecular Weight: | 10,881 Da |
| NCBI Full Name: | C-X-C motif chemokine 10 |
| NCBI Synonym Full Names: | chemokine (C-X-C motif) ligand 10 |
| NCBI Official Symbol: | CXCL10 |
| NCBI Official Synonym Symbols: | C7; IFI10; INP10; IP0; crg-2; mob; SCYB10; gIP0 |
| NCBI Protein Information: | C-X-C motif chemokine 10; gamma IP10; gamma-IP10; small-inducible cytokine B10; interferon-inducible cytokine IP0; 10 kDa interferon gamma-induced protein; protein 10 from interferon (gamma)-induced cell line; small inducible cytokine subfamily B (Cys-X-Cys), member 10 |
| UniProt Protein Name: | C-X-C motif chemokine 10 |
| UniProt Synonym Protein Names: | 10 kDa interferon gamma-induced protein; Gamma-IP10; IP0; Small-inducible cytokine B10Cleaved into the following chain:CXCL10(1-73) |
| UniProt Gene Name: | CXCL10 |
| UniProt Entry Name: | CXL10_HUMAN |
