Description
Recombinant Krs-2 Monoclonal Antibody
The Recombinant Krs-2 Monoclonal Antibody is a recombinant rabbit monoclonal antibody (clone C110799) against Krs-2. This gene encodes a serine/threonine protein kinase activated by proapoptotic molecules indicating the encoded protein functions as a growth suppressor. Cleavage of the protein product by caspase removes the inhibitory C-terminal portion. The N-terminal portion is transported to the nucleus where it homodimerizes to form the active kinase which promotes the condensation of chromatin during apoptosis. Produced by recombinant technology in Rabbit hosts and purified by Protein A affinity chromatography, this Rabbit IgG antibody is reactive against Human, Mouse and Rat samples.
This antibody is suitable for WB, IHC, IF, IP and ELISA applications. It has been validated by WB analysis of 3T3-L1. The target is localized to the cytoplasm, nucleus, The caspase-cleaved form cycles between nucleus and cytoplasm (PubMed:19525978, PubMed:11278283). Phosphorylation at Thr-117 leads to inhibition of nuclear translocation (PubMed:19525978).
| Product Name: | Recombinant Krs-2 Monoclonal Antibody |
| SKU: | AGEL6106 |
| Size: | 50 µL, 100 µL |
| Antibody Type: | Recombinant Monoclonal Antibody |
| Synonyms: | Antigen NY-CO, Antigen NY-CO-13, BCC, BCC7, Cellular tumor antigen p, Cellular tumor antigen p53, FLJ92943, Kinase responsive to stress, KRS, Krs 2, KRS2, LFS, LFS1, Mammalian STE20 like protein kinase 1, Mammalian STE20-like protein kinase 1, Mammalian sterile 20 like 1, MST, MST-1, MST1, Mutant tumor protein, Mutant tumor protein 53, p53, p53 tumor suppressor, Phosphoprotein p, Phosphoprotein p53, serine/threonine kinase, serine/threonine kinase 4, Serine/threonine protein kinase Krs 2, Serine/threonine-protein kinase 4, Serine/threonine-protein kinase Krs-2, STE20 like kinase MST1, STE20-like kinase MST1, STK, STK4, TIIAC, Tp53, Transformation related protein, Transformation related protein 53, TRP, TRP53, Tumor protein, Tumor protein 53, Tumor protein p, Tumor protein p53, Tumor suppressor p, Tumor suppressor p53, YSK, YSK3 |
| Reactivity: | Human, Mouse, Rat |
| Immunogen: | Recombinant Human Krs-2 protein |
| Applications: | WBIHCIFIPELISA |
| Clonality: | Recombinant Monoclonal |
| Clone No: | C110799 |
| Host: | Rabbit |
| Isotype: | Rabbit IgG |
| Target: | Krs-2 |
| Conjugation: | Unconjugated |
| Observed MW: | 56 kDa |
| Calculated MW: | 56 kDa |
| Recommended Dilution: | IHC 1:200-1000; WB 1:2000-10000; IF 1:200-1000; ELISA 1:5000-20000; IP 1:50-200 |
| UniProt: | Q13043 |
| Purification: | Protein A |
| Concentration: | 0.2 mg/mL |
| Buffer: | PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant. |
| Storage: | Store at -20°C valid for 12 months. Avoid freeze / thaw cycles. |
