The Recombinant LXR alpha Monoclonal Antibody is a recombinant rabbit monoclonal antibody (clone C723366) against LXR alpha. NR1H3, also known as LXRA, is a liver X receptors, which form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. It's also a ligand-activated LXRs and forms heterodimers with retinoid X receptor, then participates in regulating expression of target genes containing LXR response elements. Produced by recombinant technology in Rabbit hosts and purified by affinity chromatography, this Rabbit IgG antibody is reactive against Human and Rat samples.
This antibody is suitable for WB and IHC-P applications. It has been validated by WB analysis of Rat Rat Brain and IHC analysis of Human breast cancer. The target is localized to the nucleus.