The Recombinant MYH9 Monoclonal Antibody is a recombinant rabbit monoclonal antibody (clone C110913) against MYH9. This gene encodes a conventional non-muscle myosin; this protein should not be confused with the unconventional myosin-9a or 9b (MYO9A or MYO9B). The encoded protein is a myosin IIA heavy chain that contains an IQ domain and a myosin head-like domain which is involved in several important functions, including cytokinesis, cell motility and maintenance of cell shape. Defects in this gene have been associated with non-syndromic sensorineural deafness autosomal dominant type 17, Epstein syndrome, Alport syndrome with macrothrombocytopenia, Sebastian syndrome, Fechtner syndrome and macrothrombocytopenia with progressive sensorineural deafness. Produced by recombinant technology in Rabbit hosts and purified by Protein A affinity chromatography, this Rabbit IgG antibody is reactive against Human, Mouse and Rat samples.
This antibody is suitable for WB, IHC, IF, IP and ELISA applications. It has been validated by IHC analysis of Human kidney. The target is localized to the cytoplasm, cytoskeleton, cytoplasm, cell cortex, cytoplasmic vesicle, secretory vesicle, cortical granule, Colocalizes with actin filaments at lamellipodia margins and at the leading edge of migrating cells (PubMed:20052411). In retinal pigment epithelial cells, predominantly localized to stress fiber-like structures with some localization to cytoplasmic puncta (PubMed:27331610).
![Anti-MYH9 [R08-2C2] Monoclonal Antibody (AGMB01509)](https://cdn11.bigcommerce.com/s-h68l9z2lnx/images/stencil/590x590/products/272798/677331/anti-myh9-r08-2c2-monoclonal-antibody-agmb01509__92719.1773032305.jpg?c=2 "Anti-MYH9 [R08-2C2] Monoclonal Antibody (AGMB01509)")
